Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 955138..955688 Replicon chromosome
Accession NZ_CP093912
Organism Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)


Gene name relE Uniprot ID G4A7B4
Locus tag MQG44_RS04495 Protein ID WP_005539226.1
Coordinates 955422..955688 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag MQG44_RS04490 Protein ID WP_005539223.1
Coordinates 955138..955410 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG44_RS04460 951014..951655 + 642 WP_005546457.1 cytochrome c biogenesis protein CcdA -
MQG44_RS04465 951670..952152 + 483 WP_005552667.1 redoxin family protein -
MQG44_RS04470 952509..952643 - 135 WP_005544187.1 hypothetical protein -
MQG44_RS04475 952650..952853 - 204 WP_258305173.1 hypothetical protein -
MQG44_RS04480 952981..953154 + 174 WP_005552670.1 hypothetical protein -
MQG44_RS04485 953530..954882 + 1353 WP_005551801.1 anaerobic C4-dicarboxylate transporter DcuC -
MQG44_RS04490 955138..955410 + 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MQG44_RS04495 955422..955688 + 267 WP_005539226.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MQG44_RS04500 955720..957279 + 1560 WP_005539229.1 glutamine-hydrolyzing GMP synthase -
MQG44_RS04505 957672..958622 - 951 WP_005539231.1 hypothetical protein -
MQG44_RS04510 958816..959229 - 414 WP_005539234.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10502.03 Da        Isoelectric Point: 7.2393

>T238995 WP_005539226.1 NZ_CP093912:955422-955688 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLVLIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T238995 NZ_LR890557:55015-55497 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT238995 WP_005539223.1 NZ_CP093912:955138-955410 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp

>AT238995 NZ_LR890557:54761-55027 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FY83

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References