Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 681106..681703 Replicon chromosome
Accession NZ_CP093912
Organism Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)


Gene name relE Uniprot ID A0A142FXE8
Locus tag MQG44_RS03205 Protein ID WP_005595366.1
Coordinates 681401..681703 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID G4A710
Locus tag MQG44_RS03200 Protein ID WP_005556438.1
Coordinates 681106..681399 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG44_RS03170 676747..676926 + 180 WP_005538158.1 helix-turn-helix domain-containing protein -
MQG44_RS03175 677036..678037 - 1002 WP_005538156.1 site-specific integrase -
MQG44_RS03185 678613..679023 + 411 WP_005538154.1 CidA/LrgA family protein -
MQG44_RS03190 679023..679715 + 693 WP_258305164.1 CidB/LrgB family autolysis modulator -
MQG44_RS03195 679717..681069 + 1353 WP_005538151.1 anti-phage deoxyguanosine triphosphatase -
MQG44_RS03200 681106..681399 - 294 WP_005556438.1 putative addiction module antidote protein Antitoxin
MQG44_RS03205 681401..681703 - 303 WP_005595366.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG44_RS03210 681856..683802 + 1947 WP_005538140.1 ABC transporter ATP-binding protein -
MQG44_RS03215 683843..685054 + 1212 WP_061866516.1 hypothetical protein -
MQG44_RS03220 685057..685245 + 189 WP_236757821.1 glycoside hydrolase family 19 -
MQG44_RS03225 685194..685592 + 399 WP_005550363.1 hypothetical protein -
MQG44_RS03230 685596..686345 + 750 WP_005538836.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 673368..681703 8335


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11413.93 Da        Isoelectric Point: 5.8716

>T238993 WP_005595366.1 NZ_CP093912:c681703-681401 [Aggregatibacter actinomycetemcomitans]
MYIIEETEEFSNWLENLTDELAIVNIVARIERAKLGNFGDHKSVGNGVYEMRITKGKGYRIYYARKGGITYLLILGGDKS
SQEQDIQNAKALWQQIKNGE

Download         Length: 303 bp

>T238993 NZ_LR890556:4215243-4215590 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10694.39 Da        Isoelectric Point: 6.3545

>AT238993 WP_005556438.1 NZ_CP093912:c681399-681106 [Aggregatibacter actinomycetemcomitans]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Download         Length: 294 bp

>AT238993 NZ_LR890556:4215590-4215889 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FXE8

Antitoxin

Source ID Structure
AlphaFold DB A0A142FXE9

References