Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 282893..283485 Replicon chromosome
Accession NZ_CP093912
Organism Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MQG44_RS01375 Protein ID WP_005542431.1
Coordinates 282893..283192 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MQG44_RS01380 Protein ID WP_005542432.1
Coordinates 283189..283485 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG44_RS01350 278169..279383 - 1215 WP_005542426.1 molybdopterin molybdotransferase MoeA -
MQG44_RS01355 279512..280168 + 657 WP_005542427.1 GTP cyclohydrolase I FolE -
MQG44_RS01360 280269..281711 - 1443 WP_258305155.1 serine-type D-Ala-D-Ala carboxypeptidase -
MQG44_RS01365 281871..282347 + 477 WP_005542429.1 transcription elongation factor GreA -
MQG44_RS01370 282423..282725 - 303 WP_005542430.1 ribosome assembly RNA-binding protein YhbY -
MQG44_RS01375 282893..283192 + 300 WP_005542431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG44_RS01380 283189..283485 + 297 WP_005542432.1 putative addiction module antidote protein Antitoxin
MQG44_RS01385 283518..284132 - 615 WP_005542433.1 riboflavin synthase -
MQG44_RS01390 284159..285556 + 1398 WP_005542434.1 MATE family efflux transporter -
MQG44_RS01395 285828..287966 + 2139 WP_005542435.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hlyC / hlyB / hlyD / lsgD / lsgE / lsgF / kdsA 114379..306018 191639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11407.47 Da        Isoelectric Point: 10.4825

>T238991 WP_005542431.1 NZ_CP093912:282893-283192 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T238991 NZ_LR890556:c3788586-3788203 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10852.32 Da        Isoelectric Point: 4.3776

>AT238991 WP_005542432.1 NZ_CP093912:283189-283485 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT238991 NZ_LR890556:c3788828-3788586 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References