Detailed information of TA system TA238991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 282893..283485
• Replicon: chromosome
• Accession: NZ_CP093912
• Organism: Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MQG44_RS01375
• Protein ID: WP_005542431.1
• Coordinates: 282893..283192 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MQG44_RS01380
• Protein ID: WP_005542432.1
• Coordinates: 283189..283485 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG44_RS01350	278169..279383	-	1215	WP_005542426.1	molybdopterin molybdotransferase MoeA	-
MQG44_RS01355	279512..280168	+	657	WP_005542427.1	GTP cyclohydrolase I FolE	-
MQG44_RS01360	280269..281711	-	1443	WP_258305155.1	serine-type D-Ala-D-Ala carboxypeptidase	-
MQG44_RS01365	281871..282347	+	477	WP_005542429.1	transcription elongation factor GreA	-
MQG44_RS01370	282423..282725	-	303	WP_005542430.1	ribosome assembly RNA-binding protein YhbY	-
MQG44_RS01375	282893..283192	+	300	WP_005542431.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQG44_RS01380	283189..283485	+	297	WP_005542432.1	putative addiction module antidote protein	Antitoxin
MQG44_RS01385	283518..284132	-	615	WP_005542433.1	riboflavin synthase	-
MQG44_RS01390	284159..285556	+	1398	WP_005542434.1	MATE family efflux transporter	-
MQG44_RS01395	285828..287966	+	2139	WP_005542435.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hlyC / hlyB / hlyD / lsgD / lsgE / lsgF / kdsA	114379..306018	191639

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-90)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11407.47 Da
• Isoelectric Point: 10.4825

>T238991 WP_005542431.1 NZ_CP093912:282893-283192 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Nucleotide

• Length: 300 bp

>T238991 NZ_LR890556:c3788586-3788203 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10852.32 Da
• Isoelectric Point: 4.3776

>AT238991 WP_005542432.1 NZ_CP093912:283189-283485 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Nucleotide

• Length: 297 bp

>AT238991 NZ_LR890556:c3788828-3788586 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA