Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 253297..253799 Replicon chromosome
Accession NZ_CP093912
Organism Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)


Gene name relB Uniprot ID A0A5D0ELP0
Locus tag MQG44_RS01210 Protein ID WP_005549367.1
Coordinates 253297..253551 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A5D0ELA5
Locus tag MQG44_RS01215 Protein ID WP_005552753.1
Coordinates 253548..253799 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG44_RS01195 249231..251405 + 2175 WP_005542219.1 DNA helicase II -
MQG44_RS01200 251537..252364 - 828 WP_005542220.1 DNA ligase -
MQG44_RS01205 252541..253284 - 744 WP_005542222.1 YdcF family protein -
MQG44_RS01210 253297..253551 - 255 WP_005549367.1 Txe/YoeB family addiction module toxin Toxin
MQG44_RS01215 253548..253799 - 252 WP_005552753.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MQG44_RS01220 253908..254864 - 957 WP_005542226.1 polysaccharide pyruvyl transferase family protein -
MQG44_RS01225 254861..256384 - 1524 WP_005542228.1 hypothetical protein -
MQG44_RS01230 256518..257291 + 774 WP_258305175.1 glycosyltransferase family 25 protein -
MQG44_RS01235 257300..258490 + 1191 WP_005549375.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hlyC / hlyB / hlyD / lsgD / lsgE / lsgF / kdsA 114379..306018 191639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10203.68 Da        Isoelectric Point: 8.8844

>T238989 WP_005549367.1 NZ_CP093912:c253551-253297 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLVRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T238989 NZ_LR890556:c3311908-3311624 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9414.65 Da        Isoelectric Point: 5.0637

>AT238989 WP_005552753.1 NZ_CP093912:c253799-253548 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQFNSGKIVERE
LQE

Download         Length: 252 bp

>AT238989 NZ_LR890556:c3312140-3311898 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D0ELP0

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0ELA5

References