Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1484336..1484928 Replicon chromosome
Accession NZ_CP093911
Organism Aggregatibacter actinomycetemcomitans strain 16R

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MQG37_RS07460 Protein ID WP_012820951.1
Coordinates 1484617..1484928 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MQG37_RS07455 Protein ID WP_005545245.1
Coordinates 1484336..1484632 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG37_RS07430 1480070..1480393 - 324 WP_005575427.1 DUF1919 domain-containing protein -
MQG37_RS07435 1480449..1481420 - 972 WP_005545253.1 oxidoreductase -
MQG37_RS07440 1481481..1481960 + 480 WP_005545251.1 Cys-tRNA(Pro) deacylase -
MQG37_RS07445 1482265..1483662 - 1398 WP_005545249.1 MATE family efflux transporter -
MQG37_RS07450 1483689..1484303 + 615 WP_005575423.1 riboflavin synthase -
MQG37_RS07455 1484336..1484632 - 297 WP_005545245.1 putative addiction module antidote protein Antitoxin
MQG37_RS07460 1484617..1484928 - 312 WP_012820951.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG37_RS07465 1485096..1485398 + 303 WP_005545243.1 ribosome assembly RNA-binding protein YhbY -
MQG37_RS07470 1485473..1485949 - 477 WP_005542429.1 transcription elongation factor GreA -
MQG37_RS07475 1486110..1487552 + 1443 WP_005545239.1 serine-type D-Ala-D-Ala carboxypeptidase -
MQG37_RS07480 1487651..1488307 - 657 WP_005545236.1 GTP cyclohydrolase I FolE -
MQG37_RS07485 1488436..1489650 + 1215 WP_005545234.1 molybdopterin molybdotransferase MoeA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(6-94)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11921.03 Da        Isoelectric Point: 10.4825

>T238985 WP_012820951.1 NZ_CP093911:c1484928-1484617 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGLWVNN

Download         Length: 312 bp

>T238985 NZ_LR890556:1008536-1008853 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10853.30 Da        Isoelectric Point: 4.2702

>AT238985 WP_005545245.1 NZ_CP093911:c1484632-1484336 [Aggregatibacter actinomycetemcomitans]
MGEQLKDFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT238985 NZ_LR890556:1008929-1009225 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCCGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCAGCCAACCGGTGCAGCCAGAAAA
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References