Detailed information of TA system TA238984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1440913..1441582
• Replicon: chromosome
• Accession: NZ_CP093911
• Organism: Aggregatibacter actinomycetemcomitans strain 16R

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MQG37_RS07255
• Protein ID: WP_005573679.1
• Coordinates: 1441244..1441582 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MQG37_RS07250
• Protein ID: WP_005545810.1
• Coordinates: 1440913..1441194 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG37_RS07235	1437391..1437873	-	483	WP_005544145.1	Dps family protein	-
MQG37_RS07240	1438082..1439242	+	1161	WP_005545814.1	EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit	-
MQG37_RS07245	1439252..1440769	+	1518	WP_005545812.1	DHA2 family efflux MFS transporter permease subunit	-
MQG37_RS07250	1440913..1441194	+	282	WP_005545810.1	helix-turn-helix domain-containing protein	Antitoxin
MQG37_RS07255	1441244..1441582	+	339	WP_005573679.1	HipA N-terminal domain-containing protein	Toxin
MQG37_RS07260	1441576..1441692	+	117	WP_005545808.1	hypothetical protein	-
MQG37_RS07265	1441811..1442704	-	894	WP_005545804.1	hypothetical protein	-
MQG37_RS07270	1442771..1445635	-	2865	WP_005545802.1	valine--tRNA ligase	-
MQG37_RS07275	1445719..1446147	-	429	WP_019518326.1	DUF2726 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-88)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-64)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13104.85 Da
• Isoelectric Point: 8.6930

>T238984 WP_005573679.1 NZ_CP093911:1441244-1441582 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPDNEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Nucleotide

• Length: 339 bp

>T238984 NZ_LR890556:522261-522363 [Klebsiella pneumoniae]
GCAAGGCGGCTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10520.06 Da
• Isoelectric Point: 4.8356

>AT238984 WP_005545810.1 NZ_CP093911:1440913-1441194 [Aggregatibacter actinomycetemcomitans]
MVITIAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Nucleotide

• Length: 282 bp

>AT238984 NZ_LR890556:c522370-522225 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGCCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT