Detailed information of TA system TA238981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1317288..1317838
• Replicon: chromosome
• Accession: NZ_CP093911
• Organism: Aggregatibacter actinomycetemcomitans strain 16R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: MQG37_RS06645
• Protein ID: WP_005545988.1
• Coordinates: 1317572..1317838 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MQG37_RS06640
• Protein ID: WP_005545990.1
• Coordinates: 1317288..1317560 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG37_RS06620	1313267..1314763	-	1497	WP_005545997.1	transcription termination factor NusA	-
MQG37_RS06625	1314787..1315242	-	456	WP_005545995.1	ribosome maturation factor RimP	-
MQG37_RS06635	1315681..1317033	+	1353	WP_005545994.1	anaerobic C4-dicarboxylate transporter DcuC	-
MQG37_RS06640	1317288..1317560	+	273	WP_005545990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MQG37_RS06645	1317572..1317838	+	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MQG37_RS06650	1317870..1319429	+	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
MQG37_RS06655	1319610..1320368	+	759	WP_005545985.1	DUF4102 domain-containing protein	-
MQG37_RS06660	1320365..1320976	-	612	WP_005590093.1	DUF4376 domain-containing protein	-
MQG37_RS06665	1320976..1322214	-	1239	WP_258286245.1	phage antirepressor N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T238981 WP_005545988.1 NZ_CP093911:1317572-1317838 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T238981 NZ_LR890554:c4810330-4810046 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10165.56 Da
• Isoelectric Point: 6.2633

>AT238981 WP_005545990.1 NZ_CP093911:1317288-1317560 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKMRDLSK

Nucleotide

• Length: 273 bp

>AT238981 NZ_LR890554:c4810562-4810320 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: X2JVL6