238977

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YefM-YoeB
Location 1828032..1828534 Replicon chromosome
Accession NZ_CP093910
Organism Aggregatibacter actinomycetemcomitans strain 27R

Toxin (Protein)


Gene name relE Uniprot ID X2JX79
Locus tag MQG43_RS09060 Protein ID WP_005547296.1
Coordinates 1828032..1828283 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MQG43_RS09065 Protein ID WP_005547298.1
Coordinates 1828280..1828534 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG43_RS09040 1823302..1824495 - 1194 WP_005547286.1 hypothetical protein -
MQG43_RS09045 1824504..1825277 - 774 WP_026161168.1 glycosyltransferase family 25 protein -
MQG43_RS09050 1825411..1826970 + 1560 WP_148320583.1 polysaccharide biosynthesis protein -
MQG43_RS09055 1826967..1827923 + 957 WP_005588535.1 polysaccharide pyruvyl transferase family protein -
MQG43_RS09060 1828032..1828283 + 252 WP_005547296.1 type II toxin-antitoxin system prevent-host-death family antitoxin Toxin
MQG43_RS09065 1828280..1828534 + 255 WP_005547298.1 Txe/YoeB family addiction module toxin Antitoxin
MQG43_RS09070 1828547..1829290 + 744 WP_005542222.1 YdcF family protein -
MQG43_RS09075 1829467..1830294 + 828 Protein_1745 DNA ligase -
MQG43_RS09080 1830427..1832601 - 2175 WP_005547302.1 DNA helicase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(1-84)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9394.66 Da        Isoelectric Point: 5.0637

>T238977 WP_005547296.1 NZ_CP093910:1828032-1828283 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>T238977 NZ_LR890554:1920411-1920513 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10201.71 Da        Isoelectric Point: 8.8844

>AT238977 WP_005547298.1 NZ_CP093910:1828280-1828534 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRAPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>AT238977 NZ_LR890554:c1920520-1920375 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JX79

Antitoxin

Source ID Structure

References