Detailed information of TA system TA238975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1289200..1289750
• Replicon: chromosome
• Accession: NZ_CP093910
• Organism: Aggregatibacter actinomycetemcomitans strain 27R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: MQG43_RS06565
• Protein ID: WP_005545988.1
• Coordinates: 1289200..1289466 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MQG43_RS06570
• Protein ID: WP_005545990.1
• Coordinates: 1289478..1289750 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG43_RS06545	1284824..1286062	+	1239	WP_258271155.1	phage antirepressor N-terminal domain-containing protein	-
MQG43_RS06550	1286062..1286673	+	612	WP_005590093.1	DUF4376 domain-containing protein	-
MQG43_RS06555	1286670..1287428	-	759	WP_005545985.1	DUF4102 domain-containing protein	-
MQG43_RS06560	1287609..1289168	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
MQG43_RS06565	1289200..1289466	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MQG43_RS06570	1289478..1289750	-	273	WP_005545990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MQG43_RS06575	1290005..1291357	-	1353	WP_258271156.1	anaerobic C4-dicarboxylate transporter DcuC	-
MQG43_RS06585	1291796..1292251	+	456	WP_005545995.1	ribosome maturation factor RimP	-
MQG43_RS06590	1292275..1293771	+	1497	WP_005545997.1	transcription termination factor NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T238975 WP_005545988.1 NZ_CP093910:c1289466-1289200 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T238975 NZ_LR890554:353149-353496 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10165.56 Da
• Isoelectric Point: 6.2633

>AT238975 WP_005545990.1 NZ_CP093910:c1289750-1289478 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKMRDLSK

Nucleotide

• Length: 273 bp

>AT238975 NZ_LR890554:353496-353795 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: X2JVL6