Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1165389..1166058 Replicon chromosome
Accession NZ_CP093910
Organism Aggregatibacter actinomycetemcomitans strain 27R

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MQG43_RS05955 Protein ID WP_005573679.1
Coordinates 1165389..1165727 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MQG43_RS05960 Protein ID WP_005545810.1
Coordinates 1165777..1166058 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG43_RS05935 1160824..1161252 + 429 WP_019518326.1 DUF2726 domain-containing protein -
MQG43_RS05940 1161336..1164200 + 2865 WP_005545802.1 valine--tRNA ligase -
MQG43_RS05945 1164267..1165160 + 894 WP_005545804.1 hypothetical protein -
MQG43_RS05950 1165279..1165395 - 117 WP_005545808.1 hypothetical protein -
MQG43_RS05955 1165389..1165727 - 339 WP_005573679.1 HipA N-terminal domain-containing protein Toxin
MQG43_RS05960 1165777..1166058 - 282 WP_005545810.1 helix-turn-helix domain-containing protein Antitoxin
MQG43_RS05965 1166202..1167719 - 1518 WP_005545812.1 DHA2 family efflux MFS transporter permease subunit -
MQG43_RS05970 1167729..1168889 - 1161 WP_005545814.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
MQG43_RS05975 1169098..1169580 + 483 WP_005544145.1 Dps family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13104.85 Da        Isoelectric Point: 8.6930

>T238972 WP_005573679.1 NZ_CP093910:c1165727-1165389 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPDNEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Download         Length: 339 bp

>T238972 NZ_LR890550:80773-81189 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCCCCGCGCCATATCGAGCTGGTTGACGCGTTCTGTGCCCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCCTTGCGACAGGCCGGGACGCCGATTGGTCCGAACGACACGGCGATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTTCTGGTGACGAATAATGTAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10520.06 Da        Isoelectric Point: 4.8356

>AT238972 WP_005545810.1 NZ_CP093910:c1166058-1165777 [Aggregatibacter actinomycetemcomitans]
MVITIAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Download         Length: 282 bp

>AT238972 NZ_LR890550:80546-80776 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References