Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1122043..1122635 Replicon chromosome
Accession NZ_CP093910
Organism Aggregatibacter actinomycetemcomitans strain 27R

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MQG43_RS05755 Protein ID WP_012820951.1
Coordinates 1122043..1122354 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MQG43_RS05760 Protein ID WP_005545245.1
Coordinates 1122339..1122635 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG43_RS05730 1117321..1118535 - 1215 WP_005545234.1 molybdopterin molybdotransferase MoeA -
MQG43_RS05735 1118664..1119320 + 657 WP_005545236.1 GTP cyclohydrolase I FolE -
MQG43_RS05740 1119419..1120861 - 1443 WP_005545239.1 serine-type D-Ala-D-Ala carboxypeptidase -
MQG43_RS05745 1121022..1121498 + 477 WP_005542429.1 transcription elongation factor GreA -
MQG43_RS05750 1121573..1121875 - 303 WP_258271140.1 ribosome assembly RNA-binding protein YhbY -
MQG43_RS05755 1122043..1122354 + 312 WP_012820951.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG43_RS05760 1122339..1122635 + 297 WP_005545245.1 putative addiction module antidote protein Antitoxin
MQG43_RS05765 1122668..1123282 - 615 WP_005575423.1 riboflavin synthase -
MQG43_RS05770 1123309..1124706 + 1398 WP_005545249.1 MATE family efflux transporter -
MQG43_RS05775 1125011..1125490 - 480 WP_005545251.1 Cys-tRNA(Pro) deacylase -
MQG43_RS05780 1125551..1126522 + 972 WP_005545253.1 oxidoreductase -
MQG43_RS05785 1126578..1126901 + 324 WP_005575427.1 DUF1919 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(6-94)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11921.03 Da        Isoelectric Point: 10.4825

>T238971 WP_012820951.1 NZ_CP093910:1122043-1122354 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGLWVNN

Download         Length: 312 bp

>T238971 NZ_LR890549:53921-54403 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10853.30 Da        Isoelectric Point: 4.2702

>AT238971 WP_005545245.1 NZ_CP093910:1122339-1122635 [Aggregatibacter actinomycetemcomitans]
MGEQLKDFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT238971 NZ_LR890549:53667-53933 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References