Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4070433..4071052 Replicon chromosome
Accession NZ_CP093856
Organism Klebsiella pneumoniae strain Bio30

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MOQ79_RS19775 Protein ID WP_002892050.1
Coordinates 4070834..4071052 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MOQ79_RS19770 Protein ID WP_002892066.1
Coordinates 4070433..4070807 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ79_RS19760 (4065585) 4065585..4066778 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOQ79_RS19765 (4066801) 4066801..4069947 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MOQ79_RS19770 (4070433) 4070433..4070807 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MOQ79_RS19775 (4070834) 4070834..4071052 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MOQ79_RS19780 (4071211) 4071211..4071777 + 567 WP_002892030.1 maltose O-acetyltransferase -
MOQ79_RS19785 (4071749) 4071749..4071889 - 141 WP_004147370.1 hypothetical protein -
MOQ79_RS19790 (4071910) 4071910..4072380 + 471 WP_002892026.1 YlaC family protein -
MOQ79_RS19795 (4072355) 4072355..4073817 - 1463 Protein_3892 PLP-dependent aminotransferase family protein -
MOQ79_RS19800 (4073918) 4073918..4074616 + 699 WP_038807562.1 GNAT family protein -
MOQ79_RS19805 (4074613) 4074613..4074753 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MOQ79_RS19810 (4074753) 4074753..4075016 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T238962 WP_002892050.1 NZ_CP093856:4070834-4071052 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T238962 NZ_LR890547:827400-827810 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT238962 WP_002892066.1 NZ_CP093856:4070433-4070807 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT238962 NZ_LR890547:827153-827419 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References