Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1138896..1139376 Replicon chromosome
Accession NC_012846
Organism Bartonella grahamii as4aup

Toxin (Protein)


Gene name pasB Uniprot ID C6ADL3
Locus tag BGR_RS04800 Protein ID WP_015856325.1
Coordinates 1139107..1139376 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag BGR_RS04795 Protein ID WP_007346764.1
Coordinates 1138896..1139123 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGR_RS04750 1133991..1134242 + 252 WP_015856320.1 helix-turn-helix domain-containing protein -
BGR_RS04755 1134370..1135500 + 1131 WP_015856321.1 YdaU family protein -
BGR_RS11080 1135523..1135870 + 348 WP_172607525.1 hypothetical protein -
BGR_RS04765 1136053..1136400 + 348 WP_012754743.1 hypothetical protein -
BGR_RS04775 1137032..1137337 - 306 WP_004854238.1 BrnA antitoxin family protein -
BGR_RS04780 1137315..1137614 - 300 WP_015856322.1 BrnT family toxin -
BGR_RS04785 1137808..1138251 + 444 WP_041581404.1 single-stranded DNA-binding protein -
BGR_RS04790 1138305..1138799 + 495 WP_015856324.1 hypothetical protein -
BGR_RS04795 1138896..1139123 + 228 WP_007346764.1 ribbon-helix-helix protein, CopG family Antitoxin
BGR_RS04800 1139107..1139376 + 270 WP_015856325.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BGR_RS04810 1139927..1140412 - 486 WP_041581407.1 hypothetical protein -
BGR_RS04815 1140482..1140859 - 378 WP_041581409.1 hypothetical protein -
BGR_RS04820 1141158..1141472 + 315 WP_015856329.1 hypothetical protein -
BGR_RS04825 1141453..1142778 + 1326 WP_015856330.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1123117..1159861 36744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10448.42 Da        Isoelectric Point: 10.2009

>T23896 WP_015856325.1 NC_012846:1139107-1139376 [Bartonella grahamii as4aup]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQLSGLWRYRVGDYRILCELYDKELVVLVLAI
GHRKSIYKG

Download         Length: 270 bp

>T23896 NC_012846:1139107-1139376 [Bartonella grahamii as4aup]
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACATGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTATCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGGAGCTTGTCGTATTAGTTTTGGCTATT
GGACATAGAAAAAGCATATATAAAGGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT23896 WP_007346764.1 NC_012846:1138896-1139123 [Bartonella grahamii as4aup]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT23896 NC_012846:1138896-1139123 [Bartonella grahamii as4aup]
ATGACGATATCTATTCGATTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTGCGTGAGATTATTGAACGTGGAATAGAGGAAGCAGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A336NC70

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References