Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1450285..1450942 Replicon chromosome
Accession NZ_CP093856
Organism Klebsiella pneumoniae strain Bio30

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MOQ79_RS07275 Protein ID WP_002916310.1
Coordinates 1450285..1450695 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MOQ79_RS07280 Protein ID WP_002916312.1
Coordinates 1450676..1450942 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ79_RS07255 (1446285) 1446285..1448018 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
MOQ79_RS07260 (1448024) 1448024..1448737 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOQ79_RS07265 (1448760) 1448760..1449656 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MOQ79_RS07270 (1449757) 1449757..1450278 + 522 WP_004144730.1 flavodoxin FldB -
MOQ79_RS07275 (1450285) 1450285..1450695 - 411 WP_002916310.1 protein YgfX Toxin
MOQ79_RS07280 (1450676) 1450676..1450942 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MOQ79_RS07285 (1451188) 1451188..1452171 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
MOQ79_RS07290 (1452270) 1452270..1452929 - 660 WP_002916317.1 hemolysin III family protein -
MOQ79_RS07295 (1453093) 1453093..1453404 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MOQ79_RS07300 (1453454) 1453454..1454182 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MOQ79_RS07305 (1454301) 1454301..1455734 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T238957 WP_002916310.1 NZ_CP093856:c1450695-1450285 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T238957 NZ_LR890545:c11855-11373 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT238957 WP_002916312.1 NZ_CP093856:c1450942-1450676 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238957 NZ_LR890545:c12109-11843 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References