Detailed information of TA system TA023895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 452467..453059
• Replicon: chromosome
• Accession: NC_012846
• Organism: Bartonella grahamii as4aup

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: J1IY06
• Locus tag: BGR_RS01750
• Protein ID: WP_007553727.1
• Coordinates: 452859..453059 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: C6ABZ1
• Locus tag: BGR_RS01745
• Protein ID: WP_012754737.1
• Coordinates: 452467..452862 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BGR_RS01720	448121..448369	-	249	WP_015857126.1	hypothetical protein	-
BGR_RS01725	448373..450319	-	1947	WP_012754733.1	phage terminase large subunit family protein	-
BGR_RS01730	450309..450878	-	570	WP_012754734.1	hypothetical protein	-
BGR_RS01735	451246..451830	-	585	WP_026500577.1	hypothetical protein	-
BGR_RS01740	451834..452148	-	315	WP_026500578.1	hypothetical protein	-
BGR_RS01745	452467..452862	-	396	WP_012754737.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BGR_RS01750	452859..453059	-	201	WP_007553727.1	type II toxin-antitoxin system HicA family toxin	Toxin
BGR_RS01755	453127..453663	-	537	WP_012754738.1	hypothetical protein	-
BGR_RS01760	453675..454127	-	453	WP_026500580.1	single-stranded DNA-binding protein	-
BGR_RS01765	454429..454620	+	192	WP_004859817.1	hypothetical protein	-
BGR_RS01770	454687..455115	+	429	WP_006589119.1	type II toxin-antitoxin system HicB family antitoxin	-
BGR_RS01775	455163..455441	-	279	WP_026500581.1	hypothetical protein	-
BGR_RS01780	455438..456181	-	744	WP_012754741.1	phage antirepressor Ant	-
BGR_RS01785	456560..457075	-	516	WP_012754742.1	hypothetical protein	-
BGR_RS01790	457062..457409	-	348	WP_012754743.1	hypothetical protein	-
BGR_RS11025	457592..457939	-	348	WP_172607525.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	412088..472526	60438

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-125)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7424.82 Da
• Isoelectric Point: 11.0417

>T23895 WP_007553727.1 NC_012846:c453059-452859 [Bartonella grahamii as4aup]
MEQDSRKIIAKLKRDGFELVKVKGSHHKLKKDGKVVIVPHPKKNLPIGTARSIAQQAGWLKKGEEK

Nucleotide

• Length: 201 bp

>T23895 NC_012846:c453059-452859 [Bartonella grahamii as4aup]
ATGGAACAAGATAGCCGAAAAATCATTGCAAAATTAAAGCGTGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCTCATCA
TAAATTAAAAAAAGATGGTAAGGTTGTTATTGTTCCACATCCTAAAAAAAATCTTCCGATTGGTACAGCACGTTCTATCG
CACAACAAGCAGGTTGGTTAAAAAAAGGAGAAGAAAAATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14673.57 Da
• Isoelectric Point: 4.1492

>AT23895 WP_012754737.1 NC_012846:c452862-452467 [Bartonella grahamii as4aup]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIANATEALQLYCEDIDIVPIPSKFEEVIQRESVKIALSEGAFLI
QVPFIENDAEVVRTNISIERGLLRAIDDCAQERGLTRSAFLATAARHELNI

Nucleotide

• Length: 396 bp

>AT23895 NC_012846:c452862-452467 [Bartonella grahamii as4aup]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAAGATTCTGCTTTTGGTGTTCAGTTCCCTGATTTTGAGGGGCTTTT
TTCTGCTGCTGATGAGGAAGAAAATTTAATCGCAAATGCAACAGAAGCACTTCAACTTTATTGTGAAGATATAGATATAG
TGCCTATTCCTTCAAAATTTGAGGAAGTCATACAACGGGAATCTGTCAAAATAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTCCCCTTTATTGAAAATGATGCAGAAGTGGTACGTACGAATATATCTATTGAAAGAGGACTCTTACGTGCAATTGA
TGATTGTGCACAAGAAAGAGGTTTAACAAGATCTGCTTTTCTGGCAACAGCAGCACGTCACGAGCTTAATATTTAG

Structures

Toxin

• AlphaFold DB: J1IY06

Antitoxin

• AlphaFold DB: A0A336NHD5