Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 131300..132210 | Replicon | plasmid pBio45 |
| Accession | NZ_CP093855 | ||
| Organism | Klebsiella pneumoniae strain Bio45 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | MOQ73_RS28765 | Protein ID | WP_004181896.1 |
| Coordinates | 131300..131770 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | MOQ73_RS28770 | Protein ID | WP_004181895.1 |
| Coordinates | 131767..132210 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOQ73_RS28740 (MOQ73_28740) | 126796..127173 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| MOQ73_RS28745 (MOQ73_28745) | 127371..128345 | - | 975 | WP_043907013.1 | hypothetical protein | - |
| MOQ73_RS28750 (MOQ73_28750) | 128948..129106 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| MOQ73_RS28755 (MOQ73_28755) | 129178..130359 | + | 1182 | WP_004883380.1 | IS481 family transposase | - |
| MOQ73_RS28760 (MOQ73_28760) | 130930..131190 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| MOQ73_RS28765 (MOQ73_28765) | 131300..131770 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| MOQ73_RS28770 (MOQ73_28770) | 131767..132210 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| MOQ73_RS28775 (MOQ73_28775) | 132311..133582 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| MOQ73_RS28780 (MOQ73_28780) | 133582..134004 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| MOQ73_RS28785 (MOQ73_28785) | 134213..135349 | + | 1137 | WP_017901102.1 | tyrosine-type recombinase/integrase | - |
| MOQ73_RS28790 (MOQ73_28790) | 135415..135732 | - | 318 | WP_004026552.1 | hypothetical protein | - |
| MOQ73_RS28795 (MOQ73_28795) | 135884..136207 | - | 324 | WP_004186935.1 | hypothetical protein | - |
| MOQ73_RS28800 (MOQ73_28800) | 136204..136962 | - | 759 | WP_023287235.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) / blaOXA-232 / blaTEM-1A / dfrA14 / tet(D) / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 | rmpA / iutA / iucD / iucC / iucB / iucA | 1..337042 | 337042 | |
| - | flank | IS/Tn | - | - | 129178..130359 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T238946 WP_004181896.1 NZ_CP093855:c131770-131300 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T238946 NZ_LR890542:1858277-1858379 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT238946 WP_004181895.1 NZ_CP093855:c132210-131767 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT238946 NZ_LR890542:c1858386-1858241 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |