Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 5685351..5686261 Replicon chromosome
Accession NZ_CP093854
Organism Klebsiella pneumoniae strain Bio45

Toxin (Protein)


Gene name - Uniprot ID A0A5Q9LR54
Locus tag MOQ73_RS27740 Protein ID WP_004181896.1
Coordinates 5685791..5686261 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag MOQ73_RS27735 Protein ID WP_004181895.1
Coordinates 5685351..5685794 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ73_RS27710 (5681117) 5681117..5681749 + 633 WP_012579086.1 hypothetical protein -
MOQ73_RS27715 (5682703) 5682703..5683104 - 402 WP_012579088.1 helix-turn-helix domain-containing protein -
MOQ73_RS27720 (5683104) 5683104..5683295 - 192 WP_004187666.1 Rop family plasmid primer RNA-binding protein -
MOQ73_RS27725 (5683557) 5683557..5683979 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
MOQ73_RS27730 (5683979) 5683979..5685250 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
MOQ73_RS27735 (5685351) 5685351..5685794 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
MOQ73_RS27740 (5685791) 5685791..5686261 + 471 WP_004181896.1 RES family NAD+ phosphorylase Toxin
MOQ73_RS27745 (5686371) 5686371..5686631 - 261 WP_004026352.1 hypothetical protein -
MOQ73_RS27750 (5687462) 5687462..5688019 + 558 WP_001162012.1 recombinase family protein -
MOQ73_RS27755 (5688022) 5688022..5690994 + 2973 WP_001138073.1 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17549.81 Da        Isoelectric Point: 4.6155

>T238943 WP_004181896.1 NZ_CP093854:5685791-5686261 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T238943 NZ_LR890538:c65813-65433 [Escherichia coli]
ATGAGACATATATCACCGGAAGAACTTGTTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT238943 WP_004181895.1 NZ_CP093854:5685351-5685794 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT238943 NZ_LR890538:c66034-65813 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LR54

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References