Detailed information of TA system TA238941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 5576892..5577643
• Replicon: chromosome
• Accession: NZ_CP093854
• Organism: Klebsiella pneumoniae strain Bio45

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: MOQ73_RS27095
• Protein ID: WP_048333033.1
• Coordinates: 5577161..5577643 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A071LPN3
• Locus tag: MOQ73_RS27090
• Protein ID: WP_004902250.1
• Coordinates: 5576892..5577170 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ73_RS27055 (5572531)	5572531..5572956	-	426	WP_000522996.1	organomercurial transporter MerC	-
MOQ73_RS27060 (5572984)	5572984..5573259	-	276	WP_043907009.1	mercury resistance system periplasmic binding protein MerP	-
MOQ73_RS27065 (5573275)	5573275..5573640	-	366	WP_004200999.1	mercuric ion transporter MerT	-
MOQ73_RS27070 (5573712)	5573712..5574167	+	456	WP_001166628.1	Hg(II)-responsive transcriptional regulator	-
MOQ73_RS27075 (5574820)	5574820..5575278	+	459	WP_014386535.1	hypothetical protein	-
MOQ73_RS27080 (5576109)	5576109..5576450	+	342	WP_032437747.1	hypothetical protein	-
MOQ73_RS27085 (5576558)	5576558..5576770	+	213	WP_016946198.1	hypothetical protein	-
MOQ73_RS27090 (5576892)	5576892..5577170	+	279	WP_004902250.1	DUF1778 domain-containing protein	Antitoxin
MOQ73_RS27095 (5577161)	5577161..5577643	+	483	WP_048333033.1	GNAT family N-acetyltransferase	Toxin
MOQ73_RS27100 (5578678)	5578678..5579217	+	540	WP_004902239.1	hypothetical protein	-
MOQ73_RS27105 (5579322)	5579322..5579714	+	393	WP_032442757.1	hypothetical protein	-
MOQ73_RS27110 (5579815)	5579815..5580570	+	756	WP_004902235.1	DUF2971 domain-containing protein	-
MOQ73_RS27115 (5580597)	5580597..5581244	+	648	WP_014386537.1	EcsC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	rfaE	5360671..5607358	246687

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-86)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17708.53 Da
• Isoelectric Point: 8.9130

>T238941 WP_048333033.1 NZ_CP093854:5577161-5577643 [Klebsiella pneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Nucleotide

• Length: 483 bp

>T238941 NZ_LR890537:131172-131588 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10704.23 Da
• Isoelectric Point: 4.5271

>AT238941 WP_004902250.1 NZ_CP093854:5576892-5577170 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Nucleotide

• Length: 279 bp

>AT238941 NZ_LR890537:130945-131175 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A071LPN3