Detailed information of TA system TA238932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 5253024..5254612
• Replicon: chromosome
• Accession: NZ_CP093854
• Organism: Klebsiella pneumoniae strain Bio45

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MOQ73_RS25270
• Protein ID: WP_004179815.1
• Coordinates: 5253024..5254346 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MOQ73_RS25275
• Protein ID: WP_004176198.1
• Coordinates: 5254346..5254612 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ73_RS25255 (5248080)	5248080..5250581	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
MOQ73_RS25260 (5250569)	5250569..5251573	+	1005	WP_004179822.1	fimbrial protein	-
MOQ73_RS25265 (5251715)	5251715..5253007	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MOQ73_RS25270 (5253024)	5253024..5254346	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
MOQ73_RS25275 (5254346)	5254346..5254612	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MOQ73_RS25280 (5254878)	5254878..5255204	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
MOQ73_RS25285 (5255201)	5255201..5255701	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MOQ73_RS25290 (5255679)	5255679..5257058	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
MOQ73_RS25295 (5257404)	5257404..5258558	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MOQ73_RS25300 (5258539)	5258539..5259462	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T238932 WP_004179815.1 NZ_CP093854:c5254346-5253024 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T238932 NZ_LR890536:c4578097-4577807 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT238932 WP_004176198.1 NZ_CP093854:c5254612-5254346 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT238932 NZ_LR890536:c4578329-4578087 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA