Detailed information of TA system TA238931

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4929912..4930569
• Replicon: chromosome
• Accession: NZ_CP093854
• Organism: Klebsiella pneumoniae strain Bio45

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MOQ73_RS23565
• Protein ID: WP_004181233.1
• Coordinates: 4930159..4930569 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: MOQ73_RS23560
• Protein ID: WP_002916312.1
• Coordinates: 4929912..4930178 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ73_RS23535 (4925068)	4925068..4926501	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
MOQ73_RS23540 (4926620)	4926620..4927348	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
MOQ73_RS23545 (4927398)	4927398..4927709	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
MOQ73_RS23550 (4927873)	4927873..4928532	+	660	WP_002916317.1	hemolysin III family protein	-
MOQ73_RS23555 (4928683)	4928683..4929666	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
MOQ73_RS23560 (4929912)	4929912..4930178	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
MOQ73_RS23565 (4930159)	4930159..4930569	+	411	WP_004181233.1	protein YgfX	Toxin
MOQ73_RS23570 (4930576)	4930576..4931097	-	522	WP_004144730.1	flavodoxin FldB	-
MOQ73_RS23575 (4931198)	4931198..4932094	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
MOQ73_RS23580 (4932117)	4932117..4932830	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MOQ73_RS23585 (4932836)	4932836..4934569	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T238931 WP_004181233.1 NZ_CP093854:4930159-4930569 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T238931 NZ_LR890536:4478080-4478337 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT238931 WP_002916312.1 NZ_CP093854:4929912-4930178 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT238931 NZ_LR890536:4478349-4478900 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41