238930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4400992..4401617 Replicon chromosome
Accession NZ_CP093854
Organism Klebsiella pneumoniae strain Bio45

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag MOQ73_RS21050 Protein ID WP_002882817.1
Coordinates 4401234..4401617 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag MOQ73_RS21045 Protein ID WP_004150355.1
Coordinates 4400992..4401234 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ73_RS21020 (4396983) 4396983..4397582 + 600 WP_004151865.1 glucose-1-phosphatase -
MOQ73_RS21025 (4397576) 4397576..4398436 + 861 WP_004146232.1 virulence factor BrkB family protein -
MOQ73_RS21030 (4398433) 4398433..4398870 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
MOQ73_RS21035 (4398915) 4398915..4399856 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
MOQ73_RS21040 (4399870) 4399870..4400787 - 918 WP_004181612.1 alpha/beta hydrolase -
MOQ73_RS21045 (4400992) 4400992..4401234 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
MOQ73_RS21050 (4401234) 4401234..4401617 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
MOQ73_RS21055 (4401791) 4401791..4402720 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
MOQ73_RS21060 (4402717) 4402717..4403352 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
MOQ73_RS21065 (4403349) 4403349..4404251 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T238930 WP_002882817.1 NZ_CP093854:4401234-4401617 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T238930 NZ_LR890536:4428380-4428718 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT238930 WP_004150355.1 NZ_CP093854:4400992-4401234 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT238930 NZ_LR890536:c4428385-4428309 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References