23893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3339422..3340014 Replicon chromosome
Accession NC_012808
Organism Methylobacterium extorquens AM1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MEXAM1_RS15085 Protein ID WP_003599302.1
Coordinates 3339712..3340014 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MEXAM1_RS15080 Protein ID WP_080577052.1
Coordinates 3339422..3339712 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MEXAM1_RS15060 3335114..3336190 + 1077 WP_003599309.1 fatty acid desaturase -
MEXAM1_RS15065 3336250..3337521 - 1272 WP_012753209.1 tyrosine--tRNA ligase -
MEXAM1_RS15070 3337662..3338795 + 1134 WP_003599307.1 anhydro-N-acetylmuramic acid kinase -
MEXAM1_RS15075 3338805..3339428 + 624 WP_003599306.1 DUF3578 domain-containing protein -
MEXAM1_RS15080 3339422..3339712 - 291 WP_080577052.1 putative addiction module antidote protein Antitoxin
MEXAM1_RS15085 3339712..3340014 - 303 WP_003599302.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MEXAM1_RS15090 3340136..3341236 + 1101 WP_003599300.1 chorismate synthase -
MEXAM1_RS15095 3341365..3342444 + 1080 WP_003599298.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MEXAM1_RS15100 3342588..3343517 - 930 WP_043707076.1 histone deacetylase family protein -
MEXAM1_RS34090 3343571..3343819 - 249 WP_158022381.1 hypothetical protein -
MEXAM1_RS15105 3343818..3344453 + 636 WP_012753212.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Uncharacterized protein HI1420

(2-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11099.80 Da        Isoelectric Point: 10.2636

>T23893 WP_003599302.1 NC_012808:c3340014-3339712 [Methylorubrum extorquens AM1]
MPDIIRTRTFADWLKGLRDDRAKARIALRIDRLALGHEGDSKAVGGGVSELRIDYGPGYRIYFTYRGKTLVVLLCGGDKA
SQKRDISRAKTLATMLDGTE

Download         Length: 303 bp

>T23893 NC_012808:c3340014-3339712 [Methylorubrum extorquens AM1]
ATGCCGGACATCATCCGCACCCGAACGTTCGCGGATTGGCTGAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGTCTTGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAATTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10256.38 Da        Isoelectric Point: 4.3440

>AT23893 WP_080577052.1 NC_012808:c3339712-3339422 [Methylorubrum extorquens AM1]
MTETSPYDSAEFLESDEAVAEYLAAAIEEGDAALFRRALGVAARARGMTQIARETGLSRESLYRALSDDGNPSLDTALRV
LNALNVRLTASVASPH

Download         Length: 291 bp

>AT23893 NC_012808:c3339712-3339422 [Methylorubrum extorquens AM1]
ATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAATATCTGGCTGCGGCCAT
CGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACTCAGATCGCTCGCG
AGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAATCCGAGCCTCGACACGGCTCTGCGCGTC
CTCAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References