Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2428069..2428585 Replicon chromosome
Accession NZ_CP093854
Organism Klebsiella pneumoniae strain Bio45

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag MOQ73_RS11460 Protein ID WP_004178374.1
Coordinates 2428069..2428353 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MOQ73_RS11465 Protein ID WP_002886901.1
Coordinates 2428343..2428585 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ73_RS11435 (2423553) 2423553..2423861 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
MOQ73_RS11440 (2423946) 2423946..2424119 + 174 WP_032408826.1 hypothetical protein -
MOQ73_RS11445 (2424122) 2424122..2424865 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MOQ73_RS11450 (2425222) 2425222..2427360 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MOQ73_RS11455 (2427601) 2427601..2428065 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOQ73_RS11460 (2428069) 2428069..2428353 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOQ73_RS11465 (2428343) 2428343..2428585 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOQ73_RS11470 (2428663) 2428663..2430573 - 1911 WP_004178373.1 PRD domain-containing protein -
MOQ73_RS11475 (2430596) 2430596..2431750 - 1155 WP_004178372.1 lactonase family protein -
MOQ73_RS11480 (2431817) 2431817..2432557 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T238925 WP_004178374.1 NZ_CP093854:c2428353-2428069 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T238925 NZ_LR890536:c3802325-3802023 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCTGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT238925 WP_002886901.1 NZ_CP093854:c2428585-2428343 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT238925 NZ_LR890536:c3801987-3801646 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References