238922

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 226875..227397 Replicon plasmid pBio73
Accession NZ_CP093853
Organism Klebsiella pneumoniae strain Bio73

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag MOQ71_RS29235 Protein ID WP_038991638.1
Coordinates 226875..227159 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag MOQ71_RS29240 Protein ID WP_004181777.1
Coordinates 227149..227397 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ71_RS29200 (MOQ71_29200) 222512..222856 + 345 WP_014386518.1 hypothetical protein -
MOQ71_RS29205 (MOQ71_29205) 222853..223224 + 372 WP_044816264.1 hypothetical protein -
MOQ71_RS29210 (MOQ71_29210) 223269..224456 - 1188 WP_043907031.1 RNA-guided endonuclease TnpB family protein -
MOQ71_RS29215 (MOQ71_29215) 224492..224920 + 429 WP_077256229.1 IS200/IS605 family transposase -
MOQ71_RS29220 (MOQ71_29220) 224999..225223 + 225 Protein_239 transposase -
MOQ71_RS29225 (MOQ71_29225) 225495..226721 - 1227 WP_040120327.1 RNA-guided endonuclease TnpB family protein -
MOQ71_RS29230 (MOQ71_29230) 226757..226858 + 102 Protein_241 IS200/IS605 family transposase -
MOQ71_RS29235 (MOQ71_29235) 226875..227159 - 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOQ71_RS29240 (MOQ71_29240) 227149..227397 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOQ71_RS29245 (MOQ71_29245) 227688..229487 + 1800 WP_043907032.1 ATP-dependent helicase -
MOQ71_RS29250 (MOQ71_29250) 229821..230807 + 987 WP_040120328.1 hypothetical protein -
MOQ71_RS29255 (MOQ71_29255) 230952..231305 + 354 WP_004181774.1 hypothetical protein -
MOQ71_RS29260 (MOQ71_29260) 231367..232188 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) / blaTEM-1A / blaOXA-232 / dfrA14 / tet(D) / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 iucA / iucB / iucC / iucD / iutA / rmpA 1..332171 332171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T238922 WP_038991638.1 NZ_CP093853:c227159-226875 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T238922 NZ_LR890536:2935025-2935132 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT238922 WP_004181777.1 NZ_CP093853:c227397-227149 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT238922 NZ_LR890536:c2934975-2934918 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References