Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 122048..122799 Replicon plasmid pBio73
Accession NZ_CP093853
Organism Klebsiella pneumoniae strain Bio73

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag MOQ71_RS28675 Protein ID WP_048333033.1
Coordinates 122048..122530 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag MOQ71_RS28680 Protein ID WP_004902250.1
Coordinates 122521..122799 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ71_RS28655 (MOQ71_28655) 118447..119094 - 648 WP_014386537.1 EcsC family protein -
MOQ71_RS28660 (MOQ71_28660) 119121..119876 - 756 WP_004902235.1 DUF2971 domain-containing protein -
MOQ71_RS28665 (MOQ71_28665) 119977..120369 - 393 WP_032442757.1 hypothetical protein -
MOQ71_RS28670 (MOQ71_28670) 120474..121013 - 540 WP_004902239.1 hypothetical protein -
MOQ71_RS28675 (MOQ71_28675) 122048..122530 - 483 WP_048333033.1 GNAT family N-acetyltransferase Toxin
MOQ71_RS28680 (MOQ71_28680) 122521..122799 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
MOQ71_RS28685 (MOQ71_28685) 122921..123133 - 213 WP_016946198.1 hypothetical protein -
MOQ71_RS28690 (MOQ71_28690) 123241..123582 - 342 WP_032437747.1 hypothetical protein -
MOQ71_RS28695 (MOQ71_28695) 124413..124871 - 459 WP_014386535.1 hypothetical protein -
MOQ71_RS28700 (MOQ71_28700) 125524..125979 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
MOQ71_RS28705 (MOQ71_28705) 126051..126416 + 366 WP_004200999.1 mercuric ion transporter MerT -
MOQ71_RS28710 (MOQ71_28710) 126432..126707 + 276 WP_043907009.1 mercury resistance system periplasmic binding protein MerP -
MOQ71_RS28715 (MOQ71_28715) 126735..127160 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) / blaTEM-1A / blaOXA-232 / dfrA14 / tet(D) / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 iucA / iucB / iucC / iucD / iutA / rmpA 1..332171 332171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17708.53 Da        Isoelectric Point: 8.9130

>T238921 WP_048333033.1 NZ_CP093853:c122530-122048 [Klebsiella pneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T238921 NZ_LR890536:2934490-2934597 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT238921 WP_004902250.1 NZ_CP093853:c122799-122521 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT238921 NZ_LR890536:c2934437-2934376 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References