Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 76031..76701 | Replicon | plasmid pBio73 |
| Accession | NZ_CP093853 | ||
| Organism | Klebsiella pneumoniae strain Bio73 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | MOQ71_RS28425 | Protein ID | WP_004213072.1 |
| Coordinates | 76031..76474 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | MOQ71_RS28430 | Protein ID | WP_004213073.1 |
| Coordinates | 76471..76701 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOQ71_RS28390 (MOQ71_28390) | 71442..71717 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| MOQ71_RS28395 (MOQ71_28395) | 71768..72271 | + | 504 | WP_004145311.1 | DM13 domain-containing protein | - |
| MOQ71_RS28400 (MOQ71_28400) | 72320..73240 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| MOQ71_RS28405 (MOQ71_28405) | 73331..73734 | + | 404 | Protein_75 | GAF domain-containing protein | - |
| MOQ71_RS28410 (MOQ71_28410) | 74253..74887 | - | 635 | Protein_76 | mucoid phenotype regulator RmpA2 | - |
| MOQ71_RS28415 (MOQ71_28415) | 75304..75608 | + | 305 | Protein_77 | transposase | - |
| MOQ71_RS28420 (MOQ71_28420) | 75631..75882 | - | 252 | WP_227640036.1 | hypothetical protein | - |
| MOQ71_RS28425 (MOQ71_28425) | 76031..76474 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MOQ71_RS28430 (MOQ71_28430) | 76471..76701 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MOQ71_RS28435 (MOQ71_28435) | 77309..78442 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| MOQ71_RS28440 (MOQ71_28440) | 78458..78751 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| MOQ71_RS28445 (MOQ71_28445) | 78741..78947 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| MOQ71_RS28450 (MOQ71_28450) | 79299..79589 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| MOQ71_RS28455 (MOQ71_28455) | 79579..80478 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) / blaTEM-1A / blaOXA-232 / dfrA14 / tet(D) / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..332171 | 332171 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T238920 WP_004213072.1 NZ_CP093853:c76474-76031 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T238920 NZ_LR890536:c2694360-2694184 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT238920 WP_004213073.1 NZ_CP093853:c76701-76471 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT238920 NZ_LR890536:c2694138-2693722 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|