Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 5683645..5684555 Replicon chromosome
Accession NZ_CP093852
Organism Klebsiella pneumoniae strain Bio73

Toxin (Protein)


Gene name - Uniprot ID A0A5Q9LR54
Locus tag MOQ71_RS27720 Protein ID WP_004181896.1
Coordinates 5683645..5684115 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag MOQ71_RS27725 Protein ID WP_004181895.1
Coordinates 5684112..5684555 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ71_RS27695 (5678690) 5678690..5679091 + 402 WP_012579088.1 helix-turn-helix domain-containing protein -
MOQ71_RS27700 (5680045) 5680045..5680632 - 588 WP_242767643.1 hypothetical protein -
MOQ71_RS27705 (5680678) 5680678..5681793 - 1116 WP_012579087.1 ATP-binding protein -
MOQ71_RS27710 (5682138) 5682138..5682251 - 114 Protein_5467 replication initiation protein -
MOQ71_RS27715 (5683275) 5683275..5683535 + 261 WP_004026352.1 hypothetical protein -
MOQ71_RS27720 (5683645) 5683645..5684115 - 471 WP_004181896.1 RES family NAD+ phosphorylase Toxin
MOQ71_RS27725 (5684112) 5684112..5684555 - 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
MOQ71_RS27730 (5684656) 5684656..5685927 - 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
MOQ71_RS27735 (5685927) 5685927..5686349 - 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
MOQ71_RS27740 (5686493) 5686493..5687050 + 558 WP_001162012.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17549.81 Da        Isoelectric Point: 4.6155

>T238918 WP_004181896.1 NZ_CP093852:c5684115-5683645 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T238918 NZ_LR890536:2046328-2046582 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT238918 WP_004181895.1 NZ_CP093852:c5684555-5684112 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT238918 NZ_LR890536:2046080-2046331 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LR54

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References