Detailed information of TA system TA023891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB(toxin)
• Location: 1756044..1756502
• Replicon: chromosome
• Accession: NC_012803
• Organism: Micrococcus luteus NCTC 2665

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5CBH3
• Locus tag: MLUT_RS19525
• Protein ID: WP_010080486.1
• Coordinates: 1756044..1756298 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5CBH4
• Locus tag: MLUT_RS19530
• Protein ID: WP_010080485.1
• Coordinates: 1756299..1756502 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLUT_RS19485	1751475..1752173	-	699	WP_010080494.1	aquaporin Z	-
MLUT_RS23830	1752649..1752870	-	222	Protein_1537	hypothetical protein	-
MLUT_RS19500	1753120..1753845	+	726	WP_029248323.1	MSMEG_4193 family putative phosphomutase	-
MLUT_RS19505	1753842..1754384	+	543	WP_010080490.1	DUF3090 domain-containing protein	-
MLUT_RS19510	1754384..1755166	+	783	WP_010080489.1	SCO1664 family protein	-
MLUT_RS19520	1755476..1756042	-	567	WP_010080487.1	mismatch-specific DNA-glycosylase	-
MLUT_RS19525	1756044..1756298	-	255	WP_010080486.1	Txe/YoeB family addiction module toxin	Toxin
MLUT_RS19530	1756299..1756502	-	204	WP_010080485.1	antitoxin	Antitoxin
MLUT_RS19535	1756663..1758006	+	1344	WP_012751024.1	IS256-like element ISMlu11 family transposase	-
MLUT_RS19540	1758043..1758372	+	330	Protein_1545	transposase	-
MLUT_RS19545	1758477..1759730	-	1254	WP_010078638.1	IS256-like element ISMlu1 family transposase	-
MLUT_RS19550	1760253..1760966	+	714	WP_010080482.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9795.09 Da
• Isoelectric Point: 6.7156

>T23891 WP_010080486.1 NC_012803:c1756298-1756044 [Micrococcus luteus NCTC 2665]
MRLVSDRSAWDDCTHWQTTDRKVLQRINTLIDAALRDPLDGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Nucleotide

• Length: 255 bp

>T23891 NC_012803:c1756298-1756044 [Micrococcus luteus NCTC 2665]
ATGCGCCTCGTGTCGGACCGCTCCGCCTGGGATGACTGCACGCACTGGCAGACCACGGACCGCAAGGTCCTCCAACGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCCTCGACGGGATCGGCAAACCCGAGCAGCTGAAGTACGGCGCGGCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7374.33 Da
• Isoelectric Point: 4.5007

>AT23891 WP_010080485.1 NC_012803:c1756502-1756299 [Micrococcus luteus NCTC 2665]
VPPEFDLADWYISRHHIAPEEAPMSISASEARKTLFPLIERVTADRDAVEIVSRKGNAVLMPADGDA

Nucleotide

• Length: 204 bp

>AT23891 NC_012803:c1756502-1756299 [Micrococcus luteus NCTC 2665]
GTGCCTCCCGAGTTCGACCTCGCCGACTGGTACATAAGCAGGCACCACATCGCGCCGGAGGAGGCCCCCATGTCCATCAG
TGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGACTGCGGACCGCGACGCCGTCGAGATCGTCTCCC
GCAAGGGCAACGCCGTTCTCATGCCCGCGGACGGGGACGCCTGA

Structures

Toxin

• AlphaFold DB: C5CBH3

Antitoxin

• AlphaFold DB: C5CBH4