Detailed information of TA system TA238907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 5233431..5235019
• Replicon: chromosome
• Accession: NZ_CP093852
• Organism: Klebsiella pneumoniae strain Bio73

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MOQ71_RS25235
• Protein ID: WP_004179815.1
• Coordinates: 5233697..5235019 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MOQ71_RS25230
• Protein ID: WP_004176198.1
• Coordinates: 5233431..5233697 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ71_RS25205 (5228581)	5228581..5229504	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
MOQ71_RS25210 (5229485)	5229485..5230639	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MOQ71_RS25215 (5230985)	5230985..5232364	+	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
MOQ71_RS25220 (5232342)	5232342..5232842	+	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MOQ71_RS25225 (5232839)	5232839..5233165	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
MOQ71_RS25230 (5233431)	5233431..5233697	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MOQ71_RS25235 (5233697)	5233697..5235019	+	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
MOQ71_RS25240 (5235036)	5235036..5236328	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MOQ71_RS25245 (5236470)	5236470..5237474	-	1005	WP_004179822.1	fimbrial protein	-
MOQ71_RS25250 (5237462)	5237462..5239963	-	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaSHV-28	kdsA / iroE	5161741..5405379	243638

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T238907 WP_004179815.1 NZ_CP093852:5233697-5235019 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T238907 NZ_LR890529:79181-79465 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT238907 WP_004176198.1 NZ_CP093852:5233431-5233697 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT238907 NZ_LR890529:78943-79191 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA