Detailed information of TA system TA238906

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4883048..4883705
• Replicon: chromosome
• Accession: NZ_CP093852
• Organism: Klebsiella pneumoniae strain Bio73

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MOQ71_RS23360
• Protein ID: WP_004181233.1
• Coordinates: 4883295..4883705 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: MOQ71_RS23355
• Protein ID: WP_002916312.1
• Coordinates: 4883048..4883314 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ71_RS23330 (4878204)	4878204..4879637	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
MOQ71_RS23335 (4879756)	4879756..4880484	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
MOQ71_RS23340 (4880534)	4880534..4880845	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
MOQ71_RS23345 (4881009)	4881009..4881668	+	660	WP_002916317.1	hemolysin III family protein	-
MOQ71_RS23350 (4881819)	4881819..4882802	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
MOQ71_RS23355 (4883048)	4883048..4883314	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
MOQ71_RS23360 (4883295)	4883295..4883705	+	411	WP_004181233.1	protein YgfX	Toxin
MOQ71_RS23365 (4883712)	4883712..4884233	-	522	WP_004144730.1	flavodoxin FldB	-
MOQ71_RS23370 (4884334)	4884334..4885230	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
MOQ71_RS23375 (4885253)	4885253..4885966	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MOQ71_RS23380 (4885972)	4885972..4887705	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T238906 WP_004181233.1 NZ_CP093852:4883295-4883705 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T238906 NZ_LR890529:c65794-65312 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT238906 WP_002916312.1 NZ_CP093852:4883048-4883314 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT238906 NZ_LR890529:c66048-65782 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41