Detailed information of TA system TA238903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 4217141..4217663
• Replicon: chromosome
• Accession: NZ_CP093852
• Organism: Klebsiella pneumoniae strain Bio73

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A0C7KG00
• Locus tag: MOQ71_RS20135
• Protein ID: WP_038991638.1
• Coordinates: 4217141..4217425 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A2J4R0U8
• Locus tag: MOQ71_RS20140
• Protein ID: WP_004181777.1
• Coordinates: 4217415..4217663 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ71_RS20100 (4212778)	4212778..4213122	+	345	WP_014386518.1	hypothetical protein	-
MOQ71_RS20105 (4213119)	4213119..4213490	+	372	WP_044816264.1	hypothetical protein	-
MOQ71_RS20110 (4213535)	4213535..4214722	-	1188	WP_043907031.1	RNA-guided endonuclease TnpB family protein	-
MOQ71_RS20115 (4214758)	4214758..4215186	+	429	WP_077256229.1	IS200/IS605 family transposase	-
MOQ71_RS20120 (4215265)	4215265..4215489	+	225	Protein_3961	transposase	-
MOQ71_RS20125 (4215761)	4215761..4216987	-	1227	WP_040120327.1	RNA-guided endonuclease TnpB family protein	-
MOQ71_RS20130 (4217023)	4217023..4217124	+	102	Protein_3963	IS200/IS605 family transposase	-
MOQ71_RS20135 (4217141)	4217141..4217425	-	285	WP_038991638.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MOQ71_RS20140 (4217415)	4217415..4217663	-	249	WP_004181777.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MOQ71_RS20145 (4217954)	4217954..4219753	+	1800	WP_043907032.1	ATP-dependent helicase	-
MOQ71_RS20150 (4220087)	4220087..4221073	+	987	WP_040120328.1	hypothetical protein	-
MOQ71_RS20155 (4221218)	4221218..4221571	+	354	WP_004181774.1	hypothetical protein	-
MOQ71_RS20160 (4221633)	4221633..4222454	+	822	WP_004181772.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	galU / rmpA / iutA / iucD / iucC / iucB / iucA	4109532..4327922	218390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10993.73 Da
• Isoelectric Point: 10.6516

>T238903 WP_038991638.1 NZ_CP093852:c4217425-4217141 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Nucleotide

• Length: 285 bp

>T238903 NZ_LR890528:51970-52293 [Klebsiella pneumoniae]
ATGAACTATCTGGAGTTTGTTGAAACCAGCGCTTTCAGTGGACTGCGTAAGGAACTCATGGATGATGATGAATTCCGCGA
ACTGCAGACCTATTTACTGGAAGCCCATGATCGGGGTGACACCATCAGTCATACCGGTGGATGCAGGAAGATTCGCTGGG
GTCGCCCGGGGATGGGTAAGCGAGGTGGCGTCAGGGTGATTTACTACGTTCGTCTTGCCAGCGGCAGACTGTATCTGCTG
CTGATATACCCGAAGAATGCGAAAGATGAGCTCAGCGAGAAAGAAAAAGCCGTTATGAAGGCATTAACACAGCAGCTGAA
GTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8925.17 Da
• Isoelectric Point: 3.8209

>AT238903 WP_004181777.1 NZ_CP093852:c4217663-4217415 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Nucleotide

• Length: 249 bp

>AT238903 NZ_LR890528:52342-52644 [Klebsiella pneumoniae]
ATGGAAAAGAAACTTTTTGATGCCCTGATCAGCAGCATGGAGGAAATGGTGGCCATTGAAAATGGCCAGATCCAGCCCGC
TGCAGAACAGGTTCACCGCCATACACTGCCGGATGTGAAAGCCATTCGTAAACATGCCGGCATGAAACAGGCTGAATTTG
CAGAAGTGGTGGGGGCCAGCGTTGACCTTGTTCGCAGCTGGGAACAGCAACGGCGTGTTCCGTCGGGTATTGCGCTGAAA
ATGCTCTGCCTCATCGAGCGTGAGCCTGCACTGATTAATACGTTGCGTGGTATTCACGTCTGA

Structures

Toxin

• AlphaFold DB: A0A0C7KG00

Antitoxin

• AlphaFold DB: A0A2J4R0U8