Detailed information of TA system TA023890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 5179085..5179662
• Replicon: chromosome
• Accession: NC_012796
• Organism: Desulfovibrio magneticus RS-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: C4XRZ6
• Locus tag: DMR_RS21600
• Protein ID: WP_015863177.1
• Coordinates: 5179366..5179662 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C4XRZ5
• Locus tag: DMR_RS21595
• Protein ID: WP_015863176.1
• Coordinates: 5179085..5179378 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMR_RS21575	5174234..5176804	+	2571	WP_015863172.1	alpha-glucan family phosphorylase	-
DMR_RS21580	5177024..5177659	+	636	WP_015863173.1	class I SAM-dependent methyltransferase	-
DMR_RS21585	5177701..5177967	+	267	WP_015863174.1	hypothetical protein	-
DMR_RS21590	5178122..5178991	+	870	WP_015863175.1	hypothetical protein	-
DMR_RS21595	5179085..5179378	+	294	WP_015863176.1	ribbon-helix-helix protein, CopG family	Antitoxin
DMR_RS21600	5179366..5179662	+	297	WP_015863177.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DMR_RS21605	5179857..5181536	+	1680	WP_015863178.1	hydantoinase	-
DMR_RS21610	5181530..5182846	+	1317	WP_015863179.1	histone deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10849.64 Da
• Isoelectric Point: 9.3946

>T23890 WP_015863177.1 NC_012796:5179366-5179662 [Desulfovibrio magneticus RS-1]
MPHLKLVWTPSALLGVQRAYRFLAAKDRAAAQAAVGTIRKYAALLEKFPNAGRPADDLDPEHRELLIPFGASGYVLIYEV
HAEIILVLAVRHQKEAGY

Nucleotide

• Length: 297 bp

>T23890 NC_012796:5179366-5179662 [Desulfovibrio magneticus RS-1]
ATGCCACATTTAAAACTGGTGTGGACACCTTCCGCGCTCCTGGGCGTTCAGCGGGCCTACCGTTTCCTTGCCGCAAAGGA
CAGGGCCGCAGCGCAGGCCGCCGTGGGGACCATCAGGAAATACGCTGCTCTTCTGGAAAAATTTCCAAACGCCGGCCGTC
CGGCTGATGATCTAGACCCCGAACACCGAGAATTGCTTATTCCGTTCGGCGCGTCCGGGTATGTGCTGATCTACGAGGTT
CACGCCGAAATTATCCTGGTGCTGGCCGTGCGCCACCAAAAAGAAGCCGGATACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10949.45 Da
• Isoelectric Point: 5.5307

>AT23890 WP_015863176.1 NC_012796:5179085-5179378 [Desulfovibrio magneticus RS-1]
MPAQTHITPTSIKLPGELRDRLQNLAKARKRTPHALMLQALETYVTREEQWEALRQEALAAHEAFMLTGLHVSAKEADDW
LAELEAGNDVEPPQCHI

Nucleotide

• Length: 294 bp

>AT23890 NC_012796:5179085-5179378 [Desulfovibrio magneticus RS-1]
ATGCCGGCGCAAACGCACATAACACCGACGAGTATTAAACTTCCCGGCGAATTGCGAGATCGGCTTCAAAATCTCGCAAA
GGCTCGAAAACGCACGCCTCACGCCCTCATGCTTCAAGCACTGGAAACGTATGTGACCAGGGAAGAACAGTGGGAAGCCT
TGCGCCAGGAAGCCCTGGCCGCGCATGAGGCATTCATGCTGACGGGTCTGCATGTGTCGGCCAAAGAAGCGGACGATTGG
CTCGCCGAACTGGAAGCAGGGAACGATGTCGAGCCGCCTCAATGCCACATTTAA

Structures

Toxin

• AlphaFold DB: C4XRZ6

Antitoxin

• AlphaFold DB: C4XRZ5