Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 3556002..3556597 Replicon chromosome
Accession NZ_CP093846
Organism Streptomyces tubbatahanensis strain DSD3025

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag MMF93_RS15200 Protein ID WP_242757583.1
Coordinates 3556214..3556597 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag MMF93_RS15195 Protein ID WP_114024327.1
Coordinates 3556002..3556199 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMF93_RS15170 (MMF93_15170) 3551669..3552379 + 711 WP_242751816.1 DUF461 domain-containing protein -
MMF93_RS15175 (MMF93_15175) 3552481..3553161 - 681 WP_114024325.1 response regulator transcription factor -
MMF93_RS15180 (MMF93_15180) 3553158..3554465 - 1308 WP_242751818.1 ATP-binding protein -
MMF93_RS15185 (MMF93_15185) 3554687..3555481 + 795 WP_242751820.1 phosphate signaling complex protein PhoU -
MMF93_RS15190 (MMF93_15190) 3555651..3555815 + 165 WP_242751822.1 hypothetical protein -
MMF93_RS15195 (MMF93_15195) 3556002..3556199 + 198 WP_114024327.1 hypothetical protein Antitoxin
MMF93_RS15200 (MMF93_15200) 3556214..3556597 + 384 WP_242757583.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MMF93_RS15205 (MMF93_15205) 3556708..3557469 - 762 WP_114024329.1 phosphoglyceromutase -
MMF93_RS15210 (MMF93_15210) 3557597..3559063 + 1467 WP_242751824.1 MFS transporter -
MMF93_RS15215 (MMF93_15215) 3559025..3561133 - 2109 WP_242751826.1 GAF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(50-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13790.46 Da        Isoelectric Point: 4.3068

>T238897 WP_242757583.1 NZ_CP093846:3556214-3556597 [Streptomyces tubbatahanensis]
ITEYLDEEDVLSIAEITLGSRPGIRDWGLLSSAVQRPRSSAFGQDAYPGLFEKAAALLHSVASNHSLIDGNKRTGWATAI
VFLDLNGYELAEPLDEDKAEAFVLKVSQSRLEIGEIAENLASFVKPS

Download         Length: 384 bp

>T238897 NZ_LR890527:c3717623-3717306 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7107.19 Da        Isoelectric Point: 11.4778

>AT238897 WP_114024327.1 NZ_CP093846:3556002-3556199 [Streptomyces tubbatahanensis]
MPALNVTFSEEEMAQVREAASQEGTSVKSLAHDTVLAELRRRKVRAAALRTARISAGLNKRLATK

Download         Length: 198 bp

>AT238897 NZ_LR890527:c3717313-3717026 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACGTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References