Detailed information of TA system TA238892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1772..2319
• Replicon: plasmid unnamed2
• Accession: NZ_CP093550
• Organism: Escherichia coli strain YL03

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MPJ80_RS25045
• Protein ID: WP_244449344.1
• Coordinates: 2041..2319 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E2GHF7
• Locus tag: MPJ80_RS25040
• Protein ID: WP_012881119.1
• Coordinates: 1772..2041 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPJ80_RS25030 (1)	1..858	+	858	WP_016240488.1	incFII family plasmid replication initiator RepA	-
MPJ80_RS25035 (1559)	1559..1717	+	159	WP_032142560.1	hypothetical protein	-
MPJ80_RS25040 (1772)	1772..2041	+	270	WP_012881119.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
MPJ80_RS25045 (2041)	2041..2319	+	279	WP_244449344.1	type II toxin-antitoxin system toxin YacB	Toxin
MPJ80_RS25050 (2365)	2365..3213	+	849	WP_012881117.1	3'-5' exonuclease	-
MPJ80_RS25055 (3330)	3330..3812	+	483	WP_001311056.1	hypothetical protein	-
MPJ80_RS25060 (3847)	3847..4869	-	1023	Protein_6	maltoporin LamB	-
MPJ80_RS25065 (4918)	4918..5325	-	408	Protein_7	IS5-like element IS903B family transposase	-
MPJ80_RS25070 (5405)	5405..6280	-	876	WP_001617865.1	extended-spectrum class A beta-lactamase CTX-M-14	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-14	-	1..79537	79537
	-	flank	IS/Tn	blaCTX-M-14	-	5405..7792	2387

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10744.34 Da
• Isoelectric Point: 8.4615

>T238892 WP_244449344.1 NZ_CP093550:2041-2319 [Escherichia coli]
MEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T238892 NZ_LR890527:325912-326280 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10206.54 Da
• Isoelectric Point: 8.8735

>AT238892 WP_012881119.1 NZ_CP093550:1772-2041 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK

Nucleotide

• Length: 270 bp

>AT238892 NZ_LR890527:325694-325915 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATATGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4Y1YSD8