Detailed information of TA system TA023889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 4829229..4829706
• Replicon: chromosome
• Accession: NC_012796
• Organism: Desulfovibrio magneticus RS-1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: C4XQN2
• Locus tag: DMR_RS20115
• Protein ID: WP_015862886.1
• Coordinates: 4829437..4829706 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: DMR_RS20110
• Protein ID: WP_043601238.1
• Coordinates: 4829229..4829453 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMR_RS20095	4825150..4827006	+	1857	WP_015862882.1	4Fe-4S ferredoxin	-
DMR_RS20100	4827283..4828083	+	801	WP_043601236.1	electron transfer flavoprotein subunit beta	-
DMR_RS20105	4828094..4829113	+	1020	WP_015862884.1	electron transfer flavoprotein subunit alpha	-
DMR_RS20110	4829229..4829453	+	225	WP_043601238.1	ribbon-helix-helix domain-containing protein	Antitoxin
DMR_RS20115	4829437..4829706	+	270	WP_015862886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DMR_RS20120	4829885..4831789	-	1905	WP_015862887.1	asparagine synthase (glutamine-hydrolyzing)	-
DMR_RS20125	4831892..4833139	-	1248	WP_015862888.1	glycosyltransferase family 4 protein	-
DMR_RS20130	4833136..4834011	-	876	WP_043601241.1	methyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (2-69)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10294.98 Da
• Isoelectric Point: 10.9865

>T23889 WP_015862886.1 NC_012796:4829437-4829706 [Desulfovibrio magneticus RS-1]
MAWTIDFTPEAAKALSRLGAQAQTRIVRFLRERVAPADNPRALGEPLKGSRFSGLWRFRAGDYRILCDIEDERIRILVVL
LGHRREIYK

Nucleotide

• Length: 270 bp

>T23889 NC_012796:4829437-4829706 [Desulfovibrio magneticus RS-1]
TTGGCCTGGACGATTGATTTCACGCCCGAGGCGGCCAAGGCGTTGTCGCGTCTGGGAGCGCAAGCCCAAACGCGCATCGT
CCGGTTTTTGCGCGAACGGGTCGCGCCGGCCGACAATCCCCGCGCCCTGGGCGAACCCCTCAAGGGCTCCCGATTCTCGG
GCCTGTGGCGTTTCCGCGCCGGGGACTACCGGATTTTGTGCGACATCGAGGACGAGCGTATCCGTATTCTCGTCGTTCTT
CTCGGCCACCGCCGCGAGATTTATAAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8403.58 Da
• Isoelectric Point: 4.4128

>AT23889 WP_043601238.1 NC_012796:4829229-4829453 [Desulfovibrio magneticus RS-1]
MLTVRLPEALEARLNTLAEATKRPKSFYVREALERSLEDMEDVYLAEAALERFRASGEPAVPLAELERRLGLDD

Nucleotide

• Length: 225 bp

>AT23889 NC_012796:4829229-4829453 [Desulfovibrio magneticus RS-1]
ATGCTGACTGTCCGACTCCCCGAAGCGCTGGAGGCCCGGCTCAATACCCTGGCCGAGGCGACCAAGCGCCCCAAAAGCTT
CTATGTCCGCGAAGCGCTTGAGCGAAGCCTTGAGGATATGGAAGACGTATATCTGGCGGAAGCGGCCCTGGAGCGGTTTC
GGGCCAGCGGCGAGCCGGCCGTGCCGTTAGCGGAGCTGGAGCGTCGCCTTGGCCTGGACGATTGA

Structures

Toxin

• AlphaFold DB: C4XQN2