238887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1981..2540 Replicon plasmid unnamed1
Accession NZ_CP093549
Organism Escherichia coli strain YL03

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag MPJ80_RS24530 Protein ID WP_000421259.1
Coordinates 2265..2540 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag MPJ80_RS24525 Protein ID WP_001178087.1
Coordinates 1981..2265 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPJ80_RS24520 (46) 46..1077 + 1032 WP_000907852.1 plasmid replication initiator RepA -
MPJ80_RS24525 (1981) 1981..2265 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
MPJ80_RS24530 (2265) 2265..2540 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MPJ80_RS24535 (2646) 2646..2849 + 204 Protein_3 hypothetical protein -
MPJ80_RS24540 (3119) 3119..3385 - 267 WP_000627832.1 hypothetical protein -
MPJ80_RS24545 (3385) 3385..3879 - 495 WP_015058884.1 hypothetical protein -
MPJ80_RS24550 (3935) 3935..4537 - 603 WP_000521606.1 ProQ/FINO family protein -
MPJ80_RS24555 (4713) 4713..5765 - 1053 WP_000655519.1 hypothetical protein -
MPJ80_RS24560 (5978) 5978..6568 - 591 WP_001401589.1 hypothetical protein -
MPJ80_RS24565 (6568) 6568..6822 - 255 WP_000343106.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..89988 89988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T238887 WP_000421259.1 NZ_CP093549:2265-2540 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T238887 NZ_LR890524:1714565-1714864 [Burkholderia cepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGCGCACGCGGCATGTCGC
AGGTCGCGCGCCATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTTGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT238887 WP_001178087.1 NZ_CP093549:1981-2265 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT238887 NZ_LR890524:1714244-1714561 [Burkholderia cepacia]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCT
CGCCAAACGCCGCATTCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTATGACGTGAGGCGCGGAACGATATGGGTCATCCTGCTG
TGCGGCGGCGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9YB49


Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References