Detailed information of TA system TA238886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 5030618..5031323
• Replicon: chromosome
• Accession: NZ_CP093548
• Organism: Escherichia coli strain YL03

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: MPJ80_RS24130
• Protein ID: WP_000539521.1
• Coordinates: 5030937..5031323 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPJ80_RS24125
• Protein ID: WP_001280945.1
• Coordinates: 5030618..5030947 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPJ80_RS24110 (5025775)	5025775..5026686	+	912	WP_001236019.1	glutathione ABC transporter permease GsiD	-
MPJ80_RS24115 (5026864)	5026864..5029212	+	2349	WP_021523051.1	EAL domain-containing protein	-
MPJ80_RS24120 (5029220)	5029220..5030548	+	1329	Protein_4706	diguanylate cyclase	-
MPJ80_RS24125 (5030618)	5030618..5030947	-	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
MPJ80_RS24130 (5030937)	5030937..5031323	-	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MPJ80_RS24135 (5031549)	5031549..5032874	-	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
MPJ80_RS24140 (5033087)	5033087..5033470	+	384	WP_000497137.1	biofilm formation regulator BssR	-
MPJ80_RS24145 (5033581)	5033581..5034696	+	1116	WP_000555050.1	aldose sugar dehydrogenase YliI	-
MPJ80_RS24150 (5034693)	5034693..5035319	-	627	WP_020233670.1	glutathione S-transferase GstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T238886 WP_000539521.1 NZ_CP093548:c5031323-5030937 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T238886 NZ_LR890524:1714244-1714561 [Burkholderia cepacia]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCT
CGCCAAACGCCGCATTCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTATGACGTGAGGCGCGGAACGATATGGGTCATCCTGCTG
TGCGGCGGCGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT238886 WP_001280945.1 NZ_CP093548:c5030947-5030618 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT238886 NZ_LR890524:1714565-1714864 [Burkholderia cepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGCGCACGCGGCATGTCGC
AGGTCGCGCGCCATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTTGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA

Structures

Toxin

• AlphaFold DB: A0A829GCT6