Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4608308..4608926 Replicon chromosome
Accession NZ_CP093548
Organism Escherichia coli strain YL03

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MPJ80_RS22270 Protein ID WP_001291435.1
Coordinates 4608308..4608526 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MPJ80_RS22275 Protein ID WP_000344800.1
Coordinates 4608552..4608926 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPJ80_RS22235 (4603597) 4603597..4604169 + 573 WP_000779831.1 YbaY family lipoprotein -
MPJ80_RS22240 (4604200) 4604200..4604511 - 312 WP_000409911.1 MGMT family protein -
MPJ80_RS22250 (4604890) 4604890..4605243 + 354 WP_000878140.1 DUF1428 domain-containing protein -
MPJ80_RS22255 (4605285) 4605285..4606835 - 1551 WP_001577872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MPJ80_RS22260 (4606999) 4606999..4607469 - 471 WP_001490888.1 YlaC family protein -
MPJ80_RS22265 (4607585) 4607585..4608136 - 552 WP_001522034.1 maltose O-acetyltransferase -
MPJ80_RS22270 (4608308) 4608308..4608526 - 219 WP_001291435.1 HHA domain-containing protein Toxin
MPJ80_RS22275 (4608552) 4608552..4608926 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MPJ80_RS22280 (4609472) 4609472..4612621 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
MPJ80_RS22285 (4612644) 4612644..4613837 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T238885 WP_001291435.1 NZ_CP093548:c4608526-4608308 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238885 NZ_LR890524:c1355933-1355526 [Burkholderia cepacia]
ATGAAGTTCCTCCTGGATACCAACGCGGTGATCGCCATTCTCAAAGGCGAGCCGGCGATACTGGCCCGTTTGCATGCCTG
GCACCCGGCCGATTTCGGGATCCCCGCGATCGTCGCGCACGAGCTTTACTACGGCGCGTACAAGAGCCAGCGAGCGGCGG
CGAACGTCGCGCGTGTCGACGCGCTGCAGTTCGAGGTCGTATCGTTCGACACCGAGGATGCACAGCATGCGGGTGAAATT
CGTGCGCACCTGATCGCGGCCGGCACGCCGATCGGTCCATACGATGCATTGATCGCAGGGCAGGCGCGCGCGCGGCAACT
GGTGCTGGTCACGCACAACGTCCGCGAATTCGAGCGCGTTCCGCGGCTGCAATTCGAAGACTGGCTAGCCGAACCGAGGG
CAGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT238885 WP_000344800.1 NZ_CP093548:c4608926-4608552 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT238885 NZ_LR890524:c1356172-1355930 [Burkholderia cepacia]
ATGGATACTGCAAAGCTCTTCAAGCATGGTGGCTCGCAGGCTGTCCGGCTGCCGAAGGATTTCCGCTTCGATACGGCCGA
GGTTCGCATCCGCCGCCACGGGGCGGCCGTCATTCTCGAGCCGATGCCGCAAGACTGGGCTTGGCTGGCACCGCTGATCG
GTCCGGTGGACGCCGATTTCGAGGCTGCCGCGACCACACAGCCGTCCGCTCAGGAGCGCTCGGGCCTGGACGTGTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References