Detailed information of TA system TA238882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3994682..3995496
• Replicon: chromosome
• Accession: NZ_CP093548
• Organism: Escherichia coli strain YL03

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: MPJ80_RS19390
• Protein ID: WP_001054376.1
• Coordinates: 3995239..3995496 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: MPJ80_RS19385
• Protein ID: WP_001309181.1
• Coordinates: 3994682..3995227 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPJ80_RS19355 (3990373)	3990373..3991686	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
MPJ80_RS19360 (3991698)	3991698..3991976	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
MPJ80_RS19365 (3991973)	3991973..3993094	-	1122	WP_000010829.1	M42 family metallopeptidase	-
MPJ80_RS19370 (3993339)	3993339..3993455	-	117	Protein_3784	VOC family protein	-
MPJ80_RS19375 (3993493)	3993493..3993711	-	219	Protein_3785	hypothetical protein	-
MPJ80_RS19380 (3993880)	3993880..3994626	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
MPJ80_RS19385 (3994682)	3994682..3995227	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
MPJ80_RS19390 (3995239)	3995239..3995496	-	258	WP_001054376.1	YjhX family toxin	Toxin
MPJ80_RS19395 (3995987)	3995987..3996118	-	132	WP_001309182.1	hypothetical protein	-
MPJ80_RS19400 (3996234)	3996234..3997474	+	1241	Protein_3790	helicase YjhR	-
MPJ80_RS19405 (3997742)	3997742..3997947	-	206	Protein_3791	HNH endonuclease	-
MPJ80_RS19410 (3998057)	3998057..3999037	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
MPJ80_RS19415 (3999102)	3999102..4000208	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T238882 WP_001054376.1 NZ_CP093548:c3995496-3995239 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T238882 NZ_LR890524:467078-467590 [Burkholderia cepacia]
ATGATCCCTGTCGATACGAACGTCATGCCCGAACCGCTGCGGCGTGAGCCGAACGCGGCGGTGATCGAGTGGCTCGATGC
GCAGAACGTCGAGACGCTGTATCTCGCGGCGATCAGTCTCGCGGAATTGCGGTTCGGCATGGCTGCATTGCCGGAAGGGC
GCAGGCGGGATTGGCTGCAGCAGAGTATCGGGCAGCGTGTGCTGCCGCTGTTTCGCGGTCGGATCCTGCCGTTCGACGAC
GCGGCGAGCAGGGCGTACGCGAGCTTTTGCGCGCGGACGCGTGCCGCGGGCAATGCGATCGCGGTCACCGATGGCTACAT
CGCCGCGACGGCCGAGACAAACGGCTCGATCGTGGCCACACGCGACGTCGCGCCGTTCCAGGCGTTGGGGCTGCGCATCA
TCGATCCATGGGCCGTCCGGTTCGCGATCGCCGGTTCTTTTGGCGTGCCGAAATGCAAAACGCGCCGTGCGTGGCGGCGC
GTTTTGAATCGAACCATCAGGCTCGTTCCCTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT238882 WP_001309181.1 NZ_CP093548:c3995227-3994682 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT238882 NZ_LR890524:466842-467081 [Burkholderia cepacia]
ATGCCGGTGATCACCGTTCGAAATTTGCCCGATGAAGTGCACCGCGCGCTTCGGATCCGCGCGGCCCGACACGGGCGCAG
TACGGAAGCGGAGGTGCGCGACATCCTGGAGCAGGCCGTTCTGCCGGGCGGGCGGCTCGAGCTCGGAACGCTGCTCGCGG
AAATCGGGCGGGAAGCGGGCGATGTCGATATCGGCGTGCTGTGCGACGAGATGCCAACCGGTCCGATGAGCTTTGAATGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8