Detailed information of TA system TA238880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 3881087..3881682
• Replicon: chromosome
• Accession: NZ_CP093548
• Organism: Escherichia coli strain YL03

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: MPJ80_RS18810
• Protein ID: WP_000239581.1
• Coordinates: 3881332..3881682 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: MPJ80_RS18805
• Protein ID: WP_001223213.1
• Coordinates: 3881087..3881338 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPJ80_RS18795 (3876752)	3876752..3880531	+	3780	WP_001522396.1	autotransporter assembly complex protein TamB	-
MPJ80_RS18800 (3880534)	3880534..3880875	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
MPJ80_RS18805 (3881087)	3881087..3881338	+	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
MPJ80_RS18810 (3881332)	3881332..3881682	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
MPJ80_RS18815 (3881761)	3881761..3882291	-	531	WP_000055075.1	inorganic diphosphatase	-
MPJ80_RS18820 (3882601)	3882601..3883557	+	957	WP_001522398.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
MPJ80_RS18825 (3883690)	3883690..3885192	+	1503	WP_001522399.1	sugar ABC transporter ATP-binding protein	-
MPJ80_RS18830 (3885206)	3885206..3886228	+	1023	WP_001361374.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T238880 WP_000239581.1 NZ_CP093548:3881332-3881682 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T238880 NZ_CP093548:3881332-3881682 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT238880 WP_001223213.1 NZ_CP093548:3881087-3881338 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT238880 NZ_CP093548:3881087-3881338 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7