Detailed information of TA system TA023888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1294271..1294845
• Replicon: chromosome
• Accession: NC_012796
• Organism: Desulfovibrio magneticus RS-1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: C4XLS7
• Locus tag: DMR_RS05355
• Protein ID: WP_015859889.1
• Coordinates: 1294271..1294603 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DMR_RS05360
• Protein ID: WP_015859890.1
• Coordinates: 1294600..1294845 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMR_RS05330	1289772..1290563	-	792	WP_015859883.1	type III pantothenate kinase	-
DMR_RS05335	1290569..1291162	-	594	WP_043601520.1	arylesterase	-
DMR_RS05340	1291290..1291976	+	687	WP_015859885.1	ABC transporter ATP-binding protein	-
DMR_RS05345	1291973..1292494	+	522	WP_015859886.1	hypothetical protein	-
DMR_RS05350	1292491..1292979	+	489	WP_015859887.1	ribonuclease HI	-
DMR_RS24310	1293088..1293861	-	774	WP_148208367.1	hypothetical protein	-
DMR_RS24315	1294042..1294226	-	185	Protein_1129	nitroreductase family protein	-
DMR_RS05355	1294271..1294603	-	333	WP_015859889.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DMR_RS05360	1294600..1294845	-	246	WP_015859890.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DMR_RS05365	1295047..1295703	-	657	WP_043600131.1	SagB/ThcOx family dehydrogenase	-
DMR_RS05370	1296086..1297171	-	1086	WP_015859892.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-105)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12108.72 Da
• Isoelectric Point: 6.7168

>T23888 WP_015859889.1 NC_012796:c1294603-1294271 [Desulfovibrio magneticus RS-1]
VREYPERGDFVHLDFDPKAGHEQGGPRFGLVLSPGVYNKASGLAIVAPITSRQTGYPFEAPIPEGERCYGVVLADHTRSI
DWWARGVKIVGQASQALVEDVLARYRTLLT

Nucleotide

• Length: 333 bp

>T23888 NC_012796:c1294603-1294271 [Desulfovibrio magneticus RS-1]
GTGAGGGAGTATCCGGAGCGAGGCGATTTCGTCCACCTCGACTTCGATCCCAAGGCCGGGCACGAACAGGGCGGCCCTCG
GTTCGGCCTTGTGCTCTCGCCCGGCGTCTACAATAAGGCCTCCGGCCTGGCCATCGTGGCCCCCATCACCAGCCGGCAAA
CAGGCTATCCTTTTGAAGCGCCCATCCCCGAAGGCGAACGGTGTTACGGCGTGGTGCTGGCCGACCACACGCGCAGCATC
GACTGGTGGGCCAGAGGGGTGAAGATCGTGGGGCAGGCGTCCCAGGCCCTCGTCGAGGATGTCCTGGCGCGCTATCGCAC
GTTGCTGACCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8758.88 Da
• Isoelectric Point: 4.7205

>AT23888 WP_015859890.1 NC_012796:c1294845-1294600 [Desulfovibrio magneticus RS-1]
VETVLAKWGNSLGVRIPKGMAADAGLDAGDAVSITQSAEGIVIKKAQPKPQYRLADLVSQITDENRHEATEWGDPMGREI
W

Nucleotide

• Length: 246 bp

>AT23888 NC_012796:c1294845-1294600 [Desulfovibrio magneticus RS-1]
GTGGAAACAGTCTTGGCGAAGTGGGGAAACAGCCTTGGCGTGCGCATTCCCAAGGGCATGGCCGCCGACGCCGGGCTGGA
CGCCGGCGACGCCGTCAGCATCACCCAGTCCGCGGAAGGGATCGTGATCAAAAAGGCGCAGCCCAAACCGCAATACCGTC
TTGCCGATCTGGTCAGCCAAATCACGGACGAGAACAGGCATGAGGCCACGGAGTGGGGCGACCCCATGGGCAGGGAAATC
TGGTGA

Structures

Toxin

• AlphaFold DB: C4XLS7