Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 2459150..2460431 | Replicon | chromosome |
| Accession | NZ_CP093548 | ||
| Organism | Escherichia coli strain YL03 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A1X3JHM4 |
| Locus tag | MPJ80_RS12115 | Protein ID | WP_001114681.1 |
| Coordinates | 2459538..2460431 (+) | Length | 298 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | V0YCI1 |
| Locus tag | MPJ80_RS12110 | Protein ID | WP_000208383.1 |
| Coordinates | 2459150..2459545 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPJ80_RS12065 (2454645) | 2454645..2455130 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| MPJ80_RS12070 (2455145) | 2455145..2455621 | + | 477 | WP_001186774.1 | RadC family protein | - |
| MPJ80_RS12075 (2455684) | 2455684..2455905 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| MPJ80_RS12080 (2455924) | 2455924..2456568 | + | 645 | WP_021566525.1 | hypothetical protein | - |
| MPJ80_RS12085 (2456618) | 2456618..2456998 | + | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| MPJ80_RS12090 (2457075) | 2457075..2457452 | + | 378 | WP_000854689.1 | TA system toxin CbtA family protein | - |
| MPJ80_RS12095 (2457449) | 2457449..2457937 | + | 489 | WP_000761699.1 | DUF5983 family protein | - |
| MPJ80_RS12100 (2457954) | 2457954..2458151 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| MPJ80_RS12105 (2458236) | 2458236..2459081 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| MPJ80_RS12110 (2459150) | 2459150..2459545 | + | 396 | WP_000208383.1 | DUF6088 family protein | Antitoxin |
| MPJ80_RS12115 (2459538) | 2459538..2460431 | + | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| MPJ80_RS12120 (2460902) | 2460902..2461072 | + | 171 | Protein_2380 | IS110 family transposase | - |
| MPJ80_RS12125 (2461421) | 2461421..2461723 | + | 303 | Protein_2381 | IS21 family transposase | - |
| MPJ80_RS12130 (2461764) | 2461764..2462243 | - | 480 | Protein_2382 | IS3 family transposase | - |
| MPJ80_RS12135 (2462327) | 2462327..2463835 | - | 1509 | WP_001189111.1 | group II intron reverse transcriptase/maturase | - |
| MPJ80_RS12140 (2464508) | 2464508..2465247 | - | 740 | Protein_2384 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2445862..2462210 | 16348 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34298.40 Da Isoelectric Point: 5.9850
>T238875 WP_001114681.1 NZ_CP093548:2459538-2460431 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
>T238875 NZ_LR890515:5081742-5082059 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14608.03 Da Isoelectric Point: 11.3150
>AT238875 WP_000208383.1 NZ_CP093548:2459150-2459545 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
Download Length: 396 bp
>AT238875 NZ_LR890515:5082052-5082339 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X3JHM4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0YCI1 |