Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2456618..2457452 | Replicon | chromosome |
| Accession | NZ_CP093548 | ||
| Organism | Escherichia coli strain YL03 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A8E0IX31 |
| Locus tag | MPJ80_RS12090 | Protein ID | WP_000854689.1 |
| Coordinates | 2457075..2457452 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1X3JHN3 |
| Locus tag | MPJ80_RS12085 | Protein ID | WP_001285598.1 |
| Coordinates | 2456618..2456998 (+) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPJ80_RS12050 (2452904) | 2452904..2453359 | + | 456 | WP_064772576.1 | IrmA family protein | - |
| MPJ80_RS12055 (2453438) | 2453438..2453671 | + | 234 | WP_001119727.1 | DUF905 family protein | - |
| MPJ80_RS12060 (2453772) | 2453772..2454590 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| MPJ80_RS12065 (2454645) | 2454645..2455130 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| MPJ80_RS12070 (2455145) | 2455145..2455621 | + | 477 | WP_001186774.1 | RadC family protein | - |
| MPJ80_RS12075 (2455684) | 2455684..2455905 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| MPJ80_RS12080 (2455924) | 2455924..2456568 | + | 645 | WP_021566525.1 | hypothetical protein | - |
| MPJ80_RS12085 (2456618) | 2456618..2456998 | + | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MPJ80_RS12090 (2457075) | 2457075..2457452 | + | 378 | WP_000854689.1 | TA system toxin CbtA family protein | Toxin |
| MPJ80_RS12095 (2457449) | 2457449..2457937 | + | 489 | WP_000761699.1 | DUF5983 family protein | - |
| MPJ80_RS12100 (2457954) | 2457954..2458151 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| MPJ80_RS12105 (2458236) | 2458236..2459081 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| MPJ80_RS12110 (2459150) | 2459150..2459545 | + | 396 | WP_000208383.1 | DUF6088 family protein | - |
| MPJ80_RS12115 (2459538) | 2459538..2460431 | + | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| MPJ80_RS12120 (2460902) | 2460902..2461072 | + | 171 | Protein_2380 | IS110 family transposase | - |
| MPJ80_RS12125 (2461421) | 2461421..2461723 | + | 303 | Protein_2381 | IS21 family transposase | - |
| MPJ80_RS12130 (2461764) | 2461764..2462243 | - | 480 | Protein_2382 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2445862..2462210 | 16348 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14042.07 Da Isoelectric Point: 9.1510
>T238874 WP_000854689.1 NZ_CP093548:2457075-2457452 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T238874 NZ_LR890515:c4951807-4951589 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 127 a.a. Molecular weight: 13927.72 Da Isoelectric Point: 4.7959
>AT238874 WP_001285598.1 NZ_CP093548:2456618-2456998 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
>AT238874 NZ_LR890515:c4952208-4951834 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|