Detailed information of TA system TA023887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 521834..522461
• Replicon: chromosome
• Accession: NC_012796
• Organism: Desulfovibrio magneticus RS-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C4XHY3
• Locus tag: DMR_RS02100
• Protein ID: WP_012750028.1
• Coordinates: 521834..522025 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: C4XHY4
• Locus tag: DMR_RS02105
• Protein ID: WP_012750029.1
• Coordinates: 522036..522461 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMR_RS02080	517036..517716	-	681	WP_012750024.1	hypothetical protein	-
DMR_RS02085	517807..518697	-	891	WP_012750025.1	ABC transporter ATP-binding protein	-
DMR_RS02090	518952..520484	+	1533	WP_148208338.1	metallophosphoesterase	-
DMR_RS02095	520753..521790	+	1038	WP_148208509.1	acyltransferase	-
DMR_RS02100	521834..522025	+	192	WP_012750028.1	type II toxin-antitoxin system HicA family toxin	Toxin
DMR_RS02105	522036..522461	+	426	WP_012750029.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DMR_RS02110	522544..525057	-	2514	WP_012750030.1	leucine--tRNA ligase	-
DMR_RS02115	525125..525511	-	387	WP_043599863.1	type II toxin-antitoxin system VapC family toxin	-
DMR_RS02120	525514..525750	-	237	WP_012750032.1	hypothetical protein	-
DMR_RS02125	525781..526260	-	480	WP_012750033.1	transcription antitermination factor NusB	-
DMR_RS02130	526479..526949	-	471	WP_012750034.1	6,7-dimethyl-8-ribityllumazine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-123)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7087.19 Da
• Isoelectric Point: 11.8099

>T23887 WP_012750028.1 NC_012796:521834-522025 [Desulfovibrio magneticus RS-1]
MDSREIIRRLEADGWFRVAQAVSHLQFKHAVKPGRVTAPHPKKDLPAGTLRSIERQAGISLRS

Nucleotide

• Length: 192 bp

>T23887 NC_012796:521834-522025 [Desulfovibrio magneticus RS-1]
ATGGATAGTCGGGAGATCATACGCCGTCTTGAAGCCGACGGCTGGTTCCGCGTCGCCCAGGCCGTCTCCCATCTCCAGTT
TAAGCACGCCGTCAAGCCGGGCCGGGTGACGGCGCCGCATCCGAAAAAAGATCTTCCGGCCGGCACCCTGCGCAGCATCG
AGCGCCAAGCCGGCATCTCCCTGCGGTCCTAA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 14928.90 Da
• Isoelectric Point: 4.9435

>AT23887 WP_012750029.1 NC_012796:522036-522461 [Desulfovibrio magneticus RS-1]
VDYIAVIHKDADSDWGVSFPDFPGCVTAGETLEEARRMAAEALALHVRGLAEEGLSPPRPMTLDAVARHPDFADGVAVLV
SLPEARPKNVRVNVMLPQADLEAIDARAREQGVSRSSFLLRAARAALTGPGAGCGAWSDRA

Nucleotide

• Length: 426 bp

>AT23887 NC_012796:522036-522461 [Desulfovibrio magneticus RS-1]
GTGGACTATATCGCCGTCATCCACAAGGACGCGGATTCGGATTGGGGCGTGTCGTTCCCGGATTTTCCCGGCTGCGTCAC
GGCCGGCGAGACCCTGGAGGAAGCCCGGCGCATGGCGGCCGAGGCCCTGGCCTTGCATGTGCGCGGCCTGGCCGAGGAGG
GCCTTTCGCCGCCGCGTCCCATGACCTTGGACGCCGTGGCGCGCCATCCCGATTTCGCCGACGGCGTGGCCGTGCTCGTG
TCCCTGCCGGAAGCCAGGCCGAAAAACGTGCGTGTCAACGTCATGCTGCCCCAAGCGGATTTGGAGGCCATTGACGCCCG
AGCCAGGGAGCAAGGCGTCAGCCGTTCCTCGTTTCTGTTGCGGGCGGCCAGGGCGGCCCTGACCGGCCCTGGGGCCGGCT
GCGGGGCTTGGAGCGACCGGGCCTAA

Structures

Toxin

• AlphaFold DB: C4XHY3

Antitoxin

• AlphaFold DB: C4XHY4