Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 821458..821984 | Replicon | chromosome |
| Accession | NZ_CP093548 | ||
| Organism | Escherichia coli strain YL03 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | MPJ80_RS04195 | Protein ID | WP_000323025.1 |
| Coordinates | 821458..821745 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | MPJ80_RS04200 | Protein ID | WP_000534858.1 |
| Coordinates | 821745..821984 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPJ80_RS04145 (816482) | 816482..816697 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| MPJ80_RS04150 (816917) | 816917..817087 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| MPJ80_RS04155 (817451) | 817451..817666 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| MPJ80_RS04160 (817967) | 817967..818179 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| MPJ80_RS04165 (818234) | 818234..818323 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| MPJ80_RS04170 (818601) | 818601..819353 | - | 753 | WP_001047135.1 | antitermination protein | - |
| MPJ80_RS04175 (819367) | 819367..820416 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| MPJ80_RS04180 (820418) | 820418..820696 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| MPJ80_RS04185 (820763) | 820763..821014 | - | 252 | WP_000980994.1 | protein Rem | - |
| MPJ80_RS04190 (821231) | 821231..821386 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| MPJ80_RS04195 (821458) | 821458..821745 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| MPJ80_RS04200 (821745) | 821745..821984 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| MPJ80_RS04205 (822009) | 822009..822314 | + | 306 | WP_001326990.1 | protein YdfV | - |
| MPJ80_RS04210 (822517) | 822517..822849 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| MPJ80_RS04215 (823286) | 823286..823435 | - | 150 | WP_011443592.1 | protein YdfW | - |
| MPJ80_RS04220 (823556) | 823556..824578 | - | 1023 | Protein_836 | ISNCY family transposase | - |
| MPJ80_RS04225 (825083) | 825083..826105 | - | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| MPJ80_RS04230 (826108) | 826108..826722 | - | 615 | WP_001265627.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 789278..844159 | 54881 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T238860 WP_000323025.1 NZ_CP093548:c821745-821458 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T238860 NZ_LR890508:3919723-3920130 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT238860 WP_000534858.1 NZ_CP093548:c821984-821745 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT238860 NZ_LR890508:3919476-3919742 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|