Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1920024..1920492 Replicon chromosome
Accession NZ_CP093539
Organism Staphylococcus hominis strain C5

Toxin (Protein)


Gene name TsaT Uniprot ID A0A533IU00
Locus tag MOV58_RS09630 Protein ID WP_002448257.1
Coordinates 1920304..1920492 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A533IUW6
Locus tag MOV58_RS09625 Protein ID WP_002455569.1
Coordinates 1920024..1920281 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV58_RS09585 (MOV58_09585) 1915101..1915424 + 324 WP_002448188.1 thioredoxin family protein -
MOV58_RS09590 (MOV58_09590) 1915462..1916001 - 540 WP_002448165.1 nitroreductase -
MOV58_RS09595 (MOV58_09595) 1916071..1916796 - 726 WP_002448081.1 type I 3-dehydroquinate dehydratase -
MOV58_RS09600 (MOV58_09600) 1916958..1917380 + 423 WP_002448074.1 organic hydroperoxide resistance protein -
MOV58_RS09605 (MOV58_09605) 1917832..1918323 + 492 WP_002448223.1 GNAT family N-acetyltransferase -
MOV58_RS09610 (MOV58_09610) 1918338..1918937 - 600 WP_002448069.1 histidine phosphatase family protein -
MOV58_RS09615 (MOV58_09615) 1919132..1919374 + 243 WP_002448133.1 hypothetical protein -
MOV58_RS09620 (MOV58_09620) 1919366..1919569 - 204 WP_002448195.1 sterile alpha motif-like domain-containing protein -
MOV58_RS09625 (MOV58_09625) 1920024..1920281 + 258 WP_002455569.1 hypothetical protein Antitoxin
MOV58_RS09630 (MOV58_09630) 1920304..1920492 + 189 WP_002448257.1 hypothetical protein Toxin
MOV58_RS09635 (MOV58_09635) 1920661..1921155 + 495 WP_227944951.1 lipoprotein N-acylation protein LnsA -
MOV58_RS09640 (MOV58_09640) 1921229..1921975 + 747 WP_002448118.1 poly-gamma-glutamate hydrolase family protein -
MOV58_RS09645 (MOV58_09645) 1922052..1922336 + 285 WP_002448116.1 hypothetical protein -
MOV58_RS09650 (MOV58_09650) 1922492..1922719 + 228 WP_002455571.1 hypothetical protein -
MOV58_RS09655 (MOV58_09655) 1922852..1923568 + 717 WP_002448164.1 hypothetical protein -
MOV58_RS09660 (MOV58_09660) 1923704..1923880 + 177 WP_002448052.1 hypothetical protein -
MOV58_RS09665 (MOV58_09665) 1923935..1924876 - 942 WP_002448097.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7064.73 Da        Isoelectric Point: 9.6269

>T238846 WP_002448257.1 NZ_CP093539:1920304-1920492 [Staphylococcus hominis]
MSTHLTILLWLGIIFVVAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYILLFGIL

Download         Length: 189 bp

>T238846 NZ_LR890508:643785-645107 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGTGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10081.29 Da        Isoelectric Point: 4.4986

>AT238846 WP_002455569.1 NZ_CP093539:1920024-1920281 [Staphylococcus hominis]
MNINKLFWINIMITLLFLGFNIIVTYFPKLDDYFWLIPGLIICGLTISFSLIAAILDKNLISEIIFLTNLIIFLYYIYPL
IYNFF

Download         Length: 258 bp

>AT238846 NZ_LR890508:643519-643785 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A533IU00

Antitoxin

Source ID Structure
AlphaFold DB A0A533IUW6

References