Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-doc |
| Location | 1133419..1134044 | Replicon | chromosome |
| Accession | NZ_CP093539 | ||
| Organism | Staphylococcus hominis strain C5 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | MOV58_RS05740 | Protein ID | WP_242228792.1 |
| Coordinates | 1133649..1134044 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | MOV58_RS05735 | Protein ID | WP_242228791.1 |
| Coordinates | 1133419..1133649 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOV58_RS05675 (MOV58_05675) | 1128495..1128977 | + | 483 | WP_242228783.1 | hypothetical protein | - |
| MOV58_RS05680 (MOV58_05680) | 1129157..1129342 | + | 186 | WP_001187008.1 | hypothetical protein | - |
| MOV58_RS05685 (MOV58_05685) | 1129452..1129637 | + | 186 | WP_242228784.1 | hypothetical protein | - |
| MOV58_RS05690 (MOV58_05690) | 1129634..1129789 | + | 156 | WP_053040191.1 | transcriptional regulator | - |
| MOV58_RS05695 (MOV58_05695) | 1129815..1130087 | + | 273 | WP_071859668.1 | hypothetical protein | - |
| MOV58_RS05700 (MOV58_05700) | 1130104..1130646 | + | 543 | WP_242228785.1 | hypothetical protein | - |
| MOV58_RS05705 (MOV58_05705) | 1130639..1130815 | + | 177 | WP_195832535.1 | hypothetical protein | - |
| MOV58_RS05710 (MOV58_05710) | 1130835..1131056 | + | 222 | WP_242228786.1 | hypothetical protein | - |
| MOV58_RS05715 (MOV58_05715) | 1131056..1131781 | + | 726 | WP_242228787.1 | fructose-bisphosphatase class III | - |
| MOV58_RS05720 (MOV58_05720) | 1131774..1132091 | + | 318 | WP_242228788.1 | hypothetical protein | - |
| MOV58_RS05725 (MOV58_05725) | 1132091..1132741 | + | 651 | WP_242413982.1 | hypothetical protein | - |
| MOV58_RS05730 (MOV58_05730) | 1132741..1133259 | + | 519 | WP_242228790.1 | metallophosphoesterase | - |
| MOV58_RS05735 (MOV58_05735) | 1133419..1133649 | + | 231 | WP_242228791.1 | addiction module antitoxin | Antitoxin |
| MOV58_RS05740 (MOV58_05740) | 1133649..1134044 | + | 396 | WP_242228792.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| MOV58_RS05745 (MOV58_05745) | 1134099..1134497 | + | 399 | WP_242228793.1 | hypothetical protein | - |
| MOV58_RS05750 (MOV58_05750) | 1134481..1134750 | + | 270 | WP_242228794.1 | hypothetical protein | - |
| MOV58_RS05755 (MOV58_05755) | 1134809..1135303 | + | 495 | WP_242228795.1 | hypothetical protein | - |
| MOV58_RS05760 (MOV58_05760) | 1135307..1136107 | + | 801 | WP_242228796.1 | metallophosphoesterase | - |
| MOV58_RS05765 (MOV58_05765) | 1136186..1136812 | - | 627 | WP_242228797.1 | hypothetical protein | - |
| MOV58_RS05770 (MOV58_05770) | 1136883..1137287 | - | 405 | WP_242228798.1 | YolD-like family protein | - |
| MOV58_RS05775 (MOV58_05775) | 1137636..1138199 | - | 564 | WP_242413983.1 | hypothetical protein | - |
| MOV58_RS05780 (MOV58_05780) | 1138368..1138742 | + | 375 | WP_107639974.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1041267..1188884 | 147617 | |
| - | inside | Prophage | - | - | 1020686..1169332 | 148646 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14945.34 Da Isoelectric Point: 9.0508
>T238845 WP_242228792.1 NZ_CP093539:1133649-1134044 [Staphylococcus hominis]
MKQIVYLTEKQVIAINVKAIQNFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKTLTLEEIEAWIKGHCK
MKQIVYLTEKQVIAINVKAIQNFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKTLTLEEIEAWIKGHCK
Download Length: 396 bp
>T238845 NZ_LR890508:595191-595478 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8711.80 Da Isoelectric Point: 4.4633
>AT238845 WP_242228791.1 NZ_CP093539:1133419-1133649 [Staphylococcus hominis]
MVTTRKLRRAGNSSVVSVPTEVIEALGVTNGDNLRFNVKNNQVTIEKEVSEDEEFYRMLDETFAEYDQALKRMVEV
MVTTRKLRRAGNSSVVSVPTEVIEALGVTNGDNLRFNVKNNQVTIEKEVSEDEEFYRMLDETFAEYDQALKRMVEV
Download Length: 231 bp
>AT238845 NZ_LR890508:594952-595191 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|