Detailed information of TA system TA238844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 947102..947897
• Replicon: chromosome
• Accession: NZ_CP093539
• Organism: Staphylococcus hominis strain C5

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MOV58_RS04770
• Protein ID: WP_254388735.1
• Coordinates: 947724..947897 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MOV58_RS04765
• Protein ID: WP_002449669.1
• Coordinates: 947102..947701 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV58_RS04745 (MOV58_04745)	942918..944372	+	1455	WP_002449653.1	ABC transporter substrate-binding protein/permease	-
MOV58_RS04750 (MOV58_04750)	944365..945087	+	723	WP_002449645.1	amino acid ABC transporter ATP-binding protein	-
MOV58_RS04755 (MOV58_04755)	945349..946470	+	1122	WP_002449664.1	tRNA epoxyqueuosine(34) reductase QueG	-
MOV58_RS04760 (MOV58_04760)	946472..946942	+	471	WP_002449676.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MOV58_RS04765 (MOV58_04765)	947102..947701	+	600	WP_002449669.1	glucosamine-6-phosphate isomerase	Antitoxin
MOV58_RS04770 (MOV58_04770)	947724..947897	+	174	WP_254388735.1	SAS053 family protein	Toxin
MOV58_RS04775 (MOV58_04775)	948008..948400	+	393	WP_002449658.1	hypothetical protein	-
MOV58_RS04780 (MOV58_04780)	948539..949924	+	1386	WP_077700531.1	class II fumarate hydratase	-
MOV58_RS04785 (MOV58_04785)	950003..950827	-	825	WP_002449623.1	RluA family pseudouridine synthase	-
MOV58_RS04790 (MOV58_04790)	950965..952074	+	1110	WP_002488425.1	GAF domain-containing sensor histidine kinase	-
MOV58_RS04795 (MOV58_04795)	952089..952712	+	624	WP_002449659.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6738.16 Da
• Isoelectric Point: 4.0410

>T238844 WP_254388735.1 NZ_CP093539:947724-947897 [Staphylococcus hominis]
IFMSKDSKRNYHEDENAMVQNMNDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Nucleotide

• Length: 174 bp

>T238844 NZ_LR890508:317249-317352 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22389.25 Da
• Isoelectric Point: 4.9712

>AT238844 WP_002449669.1 NZ_CP093539:947102-947701 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNTGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT238844 NZ_LR890508:c317390-317119 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT