238843

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 818183..818712 Replicon chromosome
Accession NZ_CP093539
Organism Staphylococcus hominis strain C5

Toxin (Protein)


Gene name mazF Uniprot ID A0A657ZQB6
Locus tag MOV58_RS04000 Protein ID WP_002448688.1
Coordinates 818350..818712 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag MOV58_RS03995 Protein ID WP_002448681.1
Coordinates 818183..818353 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV58_RS03970 (MOV58_03970) 814088..814567 + 480 WP_077700810.1 PH domain-containing protein -
MOV58_RS03975 (MOV58_03975) 814557..816059 + 1503 WP_002488149.1 PH domain-containing protein -
MOV58_RS03980 (MOV58_03980) 816154..816528 + 375 WP_231098517.1 PH domain-containing protein -
MOV58_RS03985 (MOV58_03985) 816556..816909 + 354 WP_002448655.1 holo-ACP synthase -
MOV58_RS03990 (MOV58_03990) 816952..818097 + 1146 WP_002448692.1 alanine racemase -
MOV58_RS03995 (MOV58_03995) 818183..818353 + 171 WP_002448681.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MOV58_RS04000 (MOV58_04000) 818350..818712 + 363 WP_002448688.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MOV58_RS04005 (MOV58_04005) 819084..820085 + 1002 WP_002448679.1 PP2C family protein-serine/threonine phosphatase -
MOV58_RS04010 (MOV58_04010) 820171..820497 + 327 WP_002448686.1 anti-sigma factor antagonist -
MOV58_RS04015 (MOV58_04015) 820526..820978 + 453 WP_242413990.1 anti-sigma B factor RsbW -
MOV58_RS04020 (MOV58_04020) 820953..821723 + 771 WP_002455074.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13527.69 Da        Isoelectric Point: 9.3701

>T238843 WP_002448688.1 NZ_CP093539:818350-818712 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVCPQKN

Download         Length: 363 bp

>T238843 NZ_LR890508:104398-104652 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT238843 WP_002448681.1 NZ_CP093539:818183-818353 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT238843 NZ_LR890508:104150-104401 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A657ZQB6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References