238842

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 807168..807686 Replicon chromosome
Accession NZ_CP093539
Organism Staphylococcus hominis strain C5

Toxin (Protein)


Gene name TsdT Uniprot ID A0A6B8SK15
Locus tag MOV58_RS03940 Protein ID WP_002448674.1
Coordinates 807477..807686 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag MOV58_RS03935 Protein ID WP_002437530.1
Coordinates 807168..807461 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV58_RS03910 (MOV58_03910) 802391..803179 + 789 WP_002448660.1 hydroxyethylthiazole kinase -
MOV58_RS03915 (MOV58_03915) 803182..803820 + 639 WP_002448695.1 thiamine phosphate synthase -
MOV58_RS03920 (MOV58_03920) 803909..804778 + 870 WP_002455066.1 membrane protein insertase YidC -
MOV58_RS03925 (MOV58_03925) 804836..805483 - 648 WP_002448635.1 HD domain-containing protein -
MOV58_RS03930 (MOV58_03930) 805518..807002 - 1485 WP_002448646.1 cardiolipin synthase -
MOV58_RS03935 (MOV58_03935) 807168..807461 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
MOV58_RS03940 (MOV58_03940) 807477..807686 + 210 WP_002448674.1 heavy metal-associated domain-containing protein Toxin
MOV58_RS03945 (MOV58_03945) 807799..807936 + 138 WP_002437525.1 Lmo0850 family protein -
MOV58_RS03950 (MOV58_03950) 808097..809281 - 1185 WP_002455068.1 FtsW/RodA/SpoVE family cell cycle protein -
MOV58_RS03955 (MOV58_03955) 809655..810725 + 1071 WP_077700807.1 D-alanine--D-alanine ligase -
MOV58_RS03960 (MOV58_03960) 810741..812096 + 1356 WP_077700808.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7956.00 Da        Isoelectric Point: 4.0857

>T238842 WP_002448674.1 NZ_CP093539:807477-807686 [Staphylococcus hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKINVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T238842 NZ_LR890508:104150-104401 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT238842 WP_002437530.1 NZ_CP093539:807168-807461 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT238842 NZ_LR890508:104398-104652 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B8SK15

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References